Early Detection of Acute Renal Injury in Blood and Marrow Transplant Patients Using Urinary Proteomics

  • Conditions: Adult Studies, Cancer - Bone Marrow Transplantation, Cancer - Immune Deficiency and Histiocytosis
  • Gender: Female, Male

The purpose of this research study is to find out if urine obtained from patients who are undergoing a blood or marrow transplant, contains proteins that can help predict if the kidneys have been injured. Kidneys can be injured from the chemotherapy, from infections, and/or from other medications us ...More

Hybrid ImmunoTherapy (ATG/Dexamethasone/Etoposide) for HLH: The HIT-HLH trial

  • Conditions: Cancer - Immune Deficiency and Histiocytosis, Cancer - Leukemia and Lymphoma
  • Gender: Female, Male

Cincinnati Children’s is conducting a research study to evaluate the safety and effectiveness of a treatment regimen combining two previous approaches to treat patients with HLH. ...More

Investigation into the Immunologic and Molecular Basis of Primary Immune Deficiencies and Immune Regulatory Disorders

  • Conditions: Cancer - Immune Deficiency and Histiocytosis, Hematology - Fanconi Anemia, Hematology - Hemophilia, Hematology - Thrombosis, Hematology - Sickle Cell and Hemoglobin
  • Gender: Female, Male

The purpose of this research study is to help the doctors learn more about disorders of the immune system. The research doctors of the Cancer and Blood Diseases Institute at Cincinnati Children's Hospital Medical Center would like to collect blood / tissue samples from patients with a diagnosis or s ...More

NI-0501: A Study to Investigate the Safety and Efficacy of an Anti-IFNγ mAb in Children Affected by Primary Hemophagocytic Lymphohistiocytosis

  • Conditions: Cancer - Immune Deficiency and Histiocytosis
  • Gender: Female, Male

Cincinnati Children’s is participating in a research study sponsored by NovImmune S.A. to evaluate the safety, tolerability and preliminary efficacy of a new drug (NI-0501) aimed at controlling disease activity in patients diagnosed with primary hemophagocytic lymphohistiocytosis who show a ...More

Repository of Tissue Samples and Data from Patients with Fanconi Anemia

  • Conditions: Adult Studies, Cancer - Immune Deficiency and Histiocytosis, Hematology - Fanconi Anemia
  • Gender: Female, Male

The purpose of this research study is to help investigators learn more about Fanconi anemia. ...More

Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death

  • Conditions: Cancer - Immune Deficiency and Histiocytosis, Genetics - Chromosome Abnormalities
  • Gender: Female, Male

The purpose of this protocol is to find the biochemical and genetic causes of inherited immune diseases affecting lymphocytes. A second purpose is to develop new knowledge which will help research doctors find better ways to prevent, diagnosis, and treat these inherited immune diseases. ...More

The Severe Chronic Neutropenia International Registry

  • Conditions: Adult Studies, Cancer - Immune Deficiency and Histiocytosis
  • Gender: Female, Male

The purpose of this research study is to learn more about the cause and outcome for Severe Chronic Neutropenia (SCN). The objective of the Registry is to collect information on the natural course of SCN and its response to treatment with the blood stimulating factor called granulocyte colony stimula ...More

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Adult Participants or Parents of Participants:

Cincinnati Children’s is involved in research because it is very important to understanding diseases and developing ways to prevent and treat health problems in children, as well as adults. Learn more about how you can help. Contact us at clinicalstudies@cchmc.org or 513-636-0098. Or, enroll in our database to be notified about future studies by completing an online sign up form.

Sponsors and Investigators:

The Office for Clinical and Translational Research at Cincinnati Children’s provides sponsors and investigators with comprehensive support services, research tools, personnel and facilities to conduct or facilitate pediatric and adult clinical research studies. Contact us at OCTR@cchmc.org or 513-636-0314.