Who can participate?
Children and teens 6 to 17 years old with asthma who:
- Have had 2 or more asthma attacks in the last year
- Are taking a daily inhaled medication
What will happen in the study?
This study includes 15 study visits to Cincinnati Children’s over a 12 month period, up to 3 visits when your child has a cold, and visits when he/she has an asthma flare up.
Here are some of the things that will happen in this study:
We will ask you questions about your child’s health.
Your child will:
- Complete breathing tests
- Have an allergy skin test
- Submit blood, urine and nasal samples
- Be randomized (like flipping a coin) to either receive the study drug mepolizumab or a placebo (inactive) shot
The study team will ask you to call if your child starts to show signs of a cold and bring them in for a “cold” visit. The purpose of these visits is to collect samples soon after his/her cold starts. They will also ask you to bring them in if your child has an asthma attack after these visits.
Parents or guardians interested in having their child participate will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.
What are the good things that can happen from this research?
Your child may directly benefit by receiving asthma care from an asthma specialist. You will receive information about your child’s breathing and allergen tests, as well as information about taking care of your child’s asthma.
Your child’s asthma may or may not improve while in this study, but he/she will be followed closely during the study.
Overall, the information we learn from this study may lead to study doctors having a better understanding of whether mepolizumab helps children to have fewer asthma attacks.