Children, Teens and Adults with Duchenne Muscular Dystrophy Needed for Research Study

Why are we doing this research?

Cincinnati Children’s is conducting a research study, sometimes known as a clinical trial or clinical study, to learn if the drug Aldactone (spironolactone) slows down the process of scar formation in the heart in people with Duchenne Muscular Dystrophy (DMD).

Who can participate?

Children, teens and adults, 8 years and older, who:

  • Have DMD


  • Are being treated, or will be treated, with Aldactone


  • Cardiology - Heart

What will happen in the study?

This is an observational research study; therefore, we will not be using any new or investigational medication. During this study, we will be collecting information from you or your child’s electronic medical records, routine clinic visits and laboratory test follow-up visits.

The following procedures are part of the routine clinical care that you or your child receives. We will collect information from these procedures/visits as part of this research study. 

Every 6 months:   

  • Review demographic information, medical history and medication
  • Physical exam:  including height, weight and vital signs (oral temperature, blood pressure, heart rate and the number of breaths you or your child take in 60 seconds)
  • Electrocardiogram (ECG):  an electrical tracing of the heartbeat or heart rhythm
  • Blood sample:  for routine clinical laboratory testing Every year:  
  • Cardiac MRI:  a non-invasive test to see the function and structure of the heart
  • Echocardiogram (echo):  an ultrasound of the heart

If you or your child has been prescribed Aldactone (spironolactone) as part of your treatment, your doctor will also ask you to visit the nearest local laboratory on several occasions so blood samples can be collected (at 1 month, 3 months, 6 months and every 6 months thereafter you or your child begin taking Aldactone). The doctor will also ask for these tests 1 week after any dosing changes. We will collect information from your routine laboratory testing as part of this study. 

You, as a participant or as a parent/guardian, will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.     

What are the good things that can happen from this research?

You or your child may not receive any direct benefit from participating in this study. When we finish the study, we hope to know more about scarring in the heart and that this may help other people with DMD later on.  

What are the bad things that can happen from this research?

There are minimal risks associated with this study because it is observational. Possible risks will be provided to those participants, parents or guardians interested in knowing more about this study.

Will you/your child be paid to be in this research study?

Participants will not be paid for their time in this study.


Contact Us.Shruti Marwaha
Cincinnati Children’s Hospital Medical Center
Heart Institute
3333 Burnet Avenue
Cincinnati, OH  45229-3039

Study Doctor

Contact Us.Jeffrey Lynn Jefferies, MD, MPH, FAAP, FACC
Cincinnati Children’s Hospital Medical Center
Heart Institute