Clinical Trials / Research Studies
Clinical Trials / Research Studies

Study for Healthy Teens

Why are we doing this research?

Cincinnati Children’s is conducting a research study, sometimes known as a clinical trial or clinical study, to learn more about how brain activity is related to differences in the way that people feel cold and hot pain. We also seek to look at other important differences among people that are related to how they experience pain. The results of this study can help us understand how pain varies between people and lead to better treatments for pain.

Who can participate?

Healthy teens 14 to 17 years old may be eligible to participate.

This study includes a MRI (magnetic resonance imaging) scan, which uses a large magnet and radio waves to look at organs inside your body. The scan is painless. However, you should not be in this study if you are uncomfortable in tight places, have metallic inserts (braces, retainers, or devices), or neurological issues.


  • Healthy Infants, Children and Adolescent Studies

What will happen in the study?

You, as a participant or as a parent/guardian, will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.

This study is divided into two visits (on separate days):

Screening Visit

  • After you complete the consent form, you will complete a series of self-report questionnaires that ask about your health, personality, and your feelings.
  • You will undergo sensory testing using heat and cold stimuli.
  • We will take a small blood sample.
  • You will have a urine drug screen to confirm that you are not using any pain-relieving medications or other drugs, and are not pregnant (females).

This session will take no more than 4 hours.

MRI Visit

The MRI scans allow us to view the structure and function of your brain.

  • During the MRI scan you will be in a cylindrical machine for about two hours.
  • You will have a series of scans during different sensory conditions and during rest. Each series of scans takes several minutes, and there will be a rest period of a few minutes between scans. During the scans, you may receive some of the hot and cold stimuli described above and will rate the sensations with the pain scales. You will also receive scans looking at brain structure.
  • When you are outside of the scanner, you will again complete questionnaires about your personality and your feelings.
  • Including scanning and completion of questionnaires, this session will take no more than 4 hours of your time.

What are the good things that can happen from this research?

Participants are not expected to receive any direct benefit from taking part in this research study. We hope the information learned from this study will benefit other people in the future.

What are the bad things that can happen from this research?

Possible risks and side effects will be provided to and discussed with those participants, parents, or guardians interested in knowing more about this study.

Will you/your child be paid to be in this research study?

Participants may receive up to $200 for time and effort.


Cincinnati Children’s
3333 Burnet Avenue
Cincinnati, OH 45229

Study Doctor

Contact Us.Robert C. Coghill, PhD
Division of Anesthesia
Cincinnati Children’s