Study for Preteens and Teens With Inactive Juvenile Idiopathic Arthritis (JIA)

Why are we doing this research?

Cincinnati Children’s is conducting a research study, sometimes known as a clinical trial or clinical study, to learn more about how biological and behavioral factors are related to how preteens and teens with inactive juvenile idiopathic arthritis (JIA) respond to and perceive pain.

Who can participate?

Preteens and teens 12 to 17 years old who have a diagnosis of JIA that is currently inactive may be eligible to participate.


  • Arthritis
  • Rheumatology

What will happen in the study?

This study includes two study visits. The first visit will last about 1 hour, and the second visit will last about 1.5 hours. Here are some of the things that will happen in this study:

Participants will:

  • Be asked to complete a health form and other forms to determine if they are eligible for the study.
  • Complete questionnaires to help us understand their personality, how they cope with problems, how they feel about themselves, mood, sleep and emotional well-being, etc.
  • Wear an activity measurement device which looks like a watch on their wrist for one week. This device measures the amount and intensity of movement and light, as well as information about sleep, which could be related to pain.
  • Be asked to complete a daily dairy (either a paper copy or online version) each day for up to a week. The diary includes questions about sleep and symptoms he/she feels during the day. It needs to be completed in the morning after waking up and in the evening before going to bed.
  • Submit blood and saliva samples.
  • Undergo a series of short assessments to determine how their body feels pain including (he/she can say stop at any time they feel too much pain or discomfort):
    • Pressure sensations - with a handheld device that applies pressure to his/her forearm, the back of the neck and/or the lower leg
    • Cold sensations to see sensitivity to cold – by placing his/her hand into a temperature-controlled water bath
    • Pinprick sensations – with a handheld probe that will apply pulses to his/her face and hand

Parents and participants will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.

What are the good things that can happen from this research?

Being in this study may not help preteens and teens with inactive JIA right now. When we complete this study, we hope that we will know more about pain, stress and sleep. This may help teens with inactive JIA and other chronic pain conditions in the future.

What are the bad things that can happen from this research?

Possible risks and discomforts will be discussed with parents or guardians interested in learning more about the study.

Will you/your child be paid to be in this research study?

Participants will receive up to $110 for time and effort.


Contact Us.Pain Research Staff
Pain Research Center
Cincinnati Children’s Hospital Medical Center
3333 Burnet Ave.
Cincinnati, OH 45229-3039

Study Doctor

Contact Us.Christopher King, PhD
Cincinnati Children’s Hospital Medical Center