Lupus Puberty Study

Why are we doing this research?

The purpose of this study is to learn more about why systemic lupus erythematosus (SLE) is more common in females than males, and why it often seems to get worse during puberty.

Who can participate?

  • Approximately 50 participants (females and males eight- to twleve-years-old) from centers throughout US and Canada; three to five from Cincinnati Children's Hospital Medical Center
  • Approximately 13 study visits over three year study period
  • Visits will always be combined with clinic visits to your doctor; participation may increase the length of your typical  visit by 15 to 20 minutes


  • From 8 to 12 years old


  • Lupus
  • Rheumatology

What will happen in the study?

  • Physician to fill out special study forms
  • Physician exam for stage of puberty 
  • Blood and urine samples
  • Questionnaire about general health (three visits only)
  • (Optional) 1x blood and urine sample for Genetic portion of study; see informed consent form for details

Will you/your child be paid to be in this research study?

The child will receive $10 for each completed study visit.




Study Coordinator – Jamie Eaton

Study Doctor

Principal  Investigator - Hermine Brunner, MD