Early Detection of Acute Renal Injury in Blood and Marrow Transplant Patients Using Urinary Proteomics

Why are we doing this research?

The purpose of this research study is to find out if urine obtained from patients who are undergoing a blood or marrow transplant, contains proteins that can help predict if the kidneys have been injured. Kidneys can be injured from the chemotherapy, from infections, and/or from other medications used during transplantation. Early detection of kidney damage and kidney failure after blood and marrow transplantation would help us to find new ways to prevent further damage as well as find new ways to treating kidney damage and kidney failure.


  • Adult Studies
  • Bone Marrow Transplantation
  • Immune Deficiency and Histiocytosis


  • Female
  • Male

What will happen in the study?

A urine sample will be collected on the day of admission to the hospital for your transplant and then daily from day -3 through day +21 of transplant.

What are the good things that can happen from this research?

If you agree to take part in this research study, there will not be a direct medical benefit for you. The information learned from this research study may benefit other patients with an immune disorder in the future.

Will I get all the facts about the study?

If you are interested in participating in this study, you will meet with a study coordinator who will explain all of the details of the study. The study coordinator will review the consent form and will be sure that all questions are answered. The consent form describes all the procedures, risks, benefits and who to contact with questions or concerns. Study procedures will not begin until the consent has been signed by the patient (if over 18 years) or the parent/guardian of the patient.

What are the bad things that can happen from this research?

A detailed list of possible risks will be provided to those patients interested in knowing more about the study.


Angela Poston Cincinnati Children’s Hospital Medical Center
Division of Hematology/Oncology
3333 Burnet Ave. Cincinnati, Ohio 45229-3039
Phone: 513-636-8815