Shigella Vaccination Study for Healthy Adults 18 to 49 Years Old
Why are we doing this research?
We want to learn more about Shigella, a common bacterial cause of diarrhea worldwide. Knowledge from this study may be helpful in developing Shigella vaccines in the future.
Who can participate?
Adults 18 to 49 years old in generally good health may be eligible to participate.
What will happen in the study?
This study involves a health screening, two study vaccine drinks about a month apart, admission to our extended stay research unit up to 11 days about a month after the second study vaccine drink, and several follow-up visits and phone calls.
Here are some of the things that will happen in this study:
- Answer questions about your health, past or present illnesses, and medications
- Have a physical exam which includes height, weight and vital signs
- Provide blood, urine and stool samples
- If eligible after screening, receive 2 study vaccine drinks in the outpatient research clinic about a month apart, be admitted to the extended stay research unit up to 11 days about a month after the second study vaccine drink
- Drink a dose of the Shigella germs about a month after the second study vaccine drink to see if the vaccinations protected you from illness. We will be sure the Shigella germs are out of your body before you go home from the extended stay research unit.
During your stay in the extended stay research unit, study staff will be available at all times to care for you.
Adults interested in participating in this study will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.
What are the good things that can happen from this research?
There is no direct benefit to you from participating in this study. However, after we complete the study we hope to know more about Shigella infections which may be helpful in developing future Shigella vaccines.
What are the bad things that can happen from this research?
Possible risks and discomforts will be discussed with those interested in learning more about the study.
Will you/your child be paid to be in this research study?
Participants may receive up to $4500 to complete the study over 8 months.