Why are we doing this research?
Cincinnati Children’s is conducting a research study, sometimes known as a clinical trial or clinical study to learn about the effects of cholesterol, both good and bad, on heart disease.
We also want to look at blood cholesterol and compare it between teens that have type 2 diabetes, teens that are obese and teens that are normal weight.
What will happen in the study?
If you (for participants 18 years or older) or your child qualifies for this study, and you decide to participate, you will come to Cincinnati Children’s for 1 study visit.
These are the things that may happen at the study visit:
- Health assessment to measure height, weight and blood pressure
- Blood samples
- Blood vessel testing
Prior to taking the blood samples, we will ask that you or your child do not have anything to eat or drink (other than water) for 8 to 10 hours before the study visit. The blood samples will be used to measure cholesterol and possibly blood sugar/blood sugar control over the past 3 months.
You or your child may also have blood vessel testing performed, which involves 2 procedures: a SphygmoCor test and an ultrasound.
During the SphygmoCor test, a study staff member will take some body measurements, including the distance from the neck to the bottom of the sternum (breast bone) and from the sternum to the wrist. Then, electrode pads will be placed on you or your child’s chest and you will be touched with a small instrument shaped like a pen. The instrument (which does not use not use radiation/X-rays, sound waves/ultrasound, or needles) will measure the stiffness of the blood vessels.
You or your child will also have an ultrasound (echocardiogram) of your carotid arteries while lying down. Gel will be applied to the neck and then an ultrasound probe will be placed there to take pictures of the arteries.
You, as a participant or as a parent/guardian, will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.