Study for Children, Teens and Adults With a Tree Allergy to Walnuts

Why are we doing this research?

Cincinnati Children’s is conducting a research study to gain information about whether children and adults with a known allergy to walnuts are likely to be able to safely consume walnut syrup (as they may not allergic to the syrup).

Who can participate?

Children, teens and adults 7 to 80 years old who have a known allergy to walnuts may be eligible to participate. Participants should have an EpiPen at home as a precaution.

Conditions

  • Allergy - Food Allergy

What will happen in the study?

This study includes one study visit which will last about 3 hours. Here are some of the things that will happen in this study:

You or your child will:

  • Have a skin test to see if you or your child is positive for walnut tree nut and walnut syrup
  • Complete a food challenge if the skin test is positive for walnut tree nut and negative for walnut syrup (a food challenge involves eating very small amounts of the food in question to observe if there are signs of a reaction and stopped if there is a reaction)
  • Be given an antihistamine to relieve any symptoms from the food challenge
  • Be asked to stop taking all antihistamines including Allegra, Zyrtec, Xyzal and Claritin six days before having the skin tests and food challenge
  • Be asked to stop medication including Benadryl, Atarax, Periactin, Zantac, Pepcid and Tagamet before having the skin tests and food challenge

Adults interested in participating, or parents interested in having their child participate will be given a consent form that thoroughly explains all of the details of the study. A member of the study staff will review the consent form with you and will be sure that all of your questions are answered.

What are the good things that can happen from this research?

You or your child will not have a direct medical benefit. However, when we finish the study, we hope that we will know more about whether walnut syrup causes allergies in people with a walnut tree nut allergy. This may help people with walnut allergies in the future.

What are the bad things that can happen from this research?

Possible risks and discomforts will be discussed with parents or guardians interested in learning more about the study.

Will you/your child be paid to be in this research study?

Participants who undergo the food challenge will receive $50 and a bottle of locally produced maple syrup for time and effort.

Contact

Contact Us.William D. Hardie, MD
513-636-4485
william.hardie@cchmc.org
Pulmonary Medicine
Cincinnati Children’s Hospital Medical Center
3333 Burnet Ave.
Cincinnati, OH 45229-3039

Study Doctor

Contact Us.William Hardie, MD
Cincinnati Children’s Hospital Medical Center