MR spectroscopy and imaging; evaluating the effects of environmental neurotoxicants and radiation
Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Radiology Department and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist.
In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.
Education and Training
BS: Chemistry & Mathematics (Magna Cum Laude), Kentucky Wesleyan College, 1988.
MS: Chemistry, Vanderbilt University, 1991.
PhD: Chemistry, Vanderbilt University, 1993.
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.
View PubMed Publications
Brubaker CJ, Dietrich KN, Lanphear BP, Cecil KM. The influence of age of lead exposure on adult gray matter volume. Neurotoxicology. 2010 Jun;31(3):259-66. Epub 2010 Mar 11.
Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75. Epub 2009 Jul 18.
Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.
Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, Egelhoff JC, Wessel S, Elangovan I, Hornung R, Jarvis K, Lanphear BP. Decreased brain volume in adults with childhood lead exposure. PLoS Med. 2008 May 27;5(5):e112.
Walz NC, Cecil KM, Wade SL, Michaud LJ. Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. J Neurotrauma. 2008 Feb;25(2):94-103.
Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1919-25. Epub 2007 Sep 28.
Cecil KM, Kos RS. Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders. Top Magn Reson Imaging. 2006 Aug;17(4):275-93. Review.
Dinopoulos A, Gorospe JR, Egelhoff JC, Cecil KM, Nicolaidou P, Morehart P, DeGrauw T. Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease. AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2088-92. Review.
Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM. Lithium treatment effects on Myo-inositol in adolescents with bipolar depression. Biol Psychiatry. 2006 Nov 1;60(9):998-1004.
Neurobehavioral Late-Effects in Pediatric Brain Tumors. Co-investigator. National Institutes of Health. 2005-2011. #R01 CA112182.
Effects of Lead, Manganese and Stress During Development. Co-investigator. National Institutes of Health. 2006-2011. #R01 ES015689.
Bipolar Disorder Imaging & Treatment Research Center. Co-Investigator. National Institutes of Health. 2007-2012. #P50 MH077138.
Neurofunctional and Neurochemical Markers of Treatment Response in Early Onset Bipolar Mania. Co-investigator. National Institutes of Health. 2007-2012. #R01 MH07043.
Early Lead Exposure, ADHD and Persistent Criminality. Co-Principal Investigator. National Institutes of Health. 2007-2012. #R01 ES015559.