Biographies

Lee A. Denson, MD

Medical Director, Inflammatory Bowel Disease Center

Professor, UC Department of Pediatrics

Phone: 513-636-7575

Email: lee.denson@cchmc.org

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Specialties

Inflammatory bowel disease; growth failure; celiac disease

Visit the Denson Lab.

Biography

The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).

Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.

We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.

Education and Training

MD: Medical College of Virginia, Richmond, VA, 1993

Residency: Yale-New Haven Hospital, New Haven, CT, 1993-96.

Certification: Pediatrics, 1996 & 2002.

Fellowship: Yale University School of Medicine, New Haven, CT, 1996-99.

Publications

View PubMed Publications