Dr. Hogenesch is an Ohio Eminent Scholar and professor of Pediatrics at Cincinnati Children's Hospital Medical Center in the Divisions of Human Genetics and Immunobiology within the UC Department of Pediatrics. His lab studies genome biology with a focus on the molecular mechanisms of circadian rhythms in mammals. Dr. Hogenesch discovered several new bHLH-PAS transcription factors, including the hypoxia inducible factors, as well as the core clock components, Npas2, Bmal2, Rora, and Bmal1, the only required component of the mammalian circadian clock. Dr. Hogenesch also pioneered the discovery of clock regulated gene expression in plants, flies, mice, and man. As a genome biologist, Dr. Hogenesch's lab applies and integrates various disciplines including bioinformatics, genomics, molecular and cellular biology, and genetics.

Before moving to Cincinnati, Dr. Hogenesch was professor and vice chair of Pharmacology at the University of Pennsylvania Perelman School of Medicine. He did his PhD in Neuroscience at Northwestern University. Currently, Dr. Hogenesch is a Penn Fellow, sits or has sat on the Scientific Advisory Boards of Qiagen, Mimetics, Bio-Rad, the Ryan Licht Sang Foundation Medical Committee, and the Gene Ontology (GO) consortium, and is an advisor to several National Institutes of Health, NIDDK, NCI, NHLBI, and the Environmental Protection Agency (EPA).