I am board-certified in otolaryngology (ear, nose and throat) and sleep medicine. My clinical focus is on diagnosing and treating upper and lower airway disorders, obstructive sleep apnea syndrome and other sleep and circadian conditions in children.
Obstructive sleep apnea is a serious sleep disorder. It occurs when breathing becomes repeatedly blocked while asleep, leading to reduced oxygen levels throughout the body. Throughout my career, I have spent much of my time treating children with obstructive sleep apnea and evaluating the risks for heart and lung disease in this population. While healthcare providers have multiple medical and surgical techniques to treat this disorder, there are many gaps in knowledge regarding how this condition changes over time.
We all have an internal clock that prepares the body to exercise, eat, digest and sleep at specific times of the day. In my lab, we are studying how disruption of this circadian clock occurs in the setting of obstructive sleep apnea. Using animal models, our efforts are aimed at better understanding this disease process and creating new treatments for obstructive sleep apnea.
At Cincinnati Children’s Hospital Medical Center, I work closely with Dr. John Hogenesch and other circadian biologists to evaluate the role of the circadian clock in other diseases. We are using information from our labs to better understand human health and develop new treatments for disease. Along with these efforts, we have developed the Center for Circadian Medicine. More globally, our efforts are aimed at improving diagnostic procedures for children with circadian disorders, standardizing treatments for children with sleep disorders and determining how sleep disruption impacts other diseases. This bench-to-bedside approach can change the way we practice medicine.
Throughout my career, I have received multiple awards, including:
As a surgeon and a scientist, my objective is to bridge the gap between research and clinical care. We endeavor to take new results uncovered in the lab and apply them to patient care. We are looking for methods to enhance treatment for children with sleep and circadian conditions.
Otolaryngology - head and neck surgery; pediatric otolaryngology; sleep medicine; airway disorders
Pulmonary Medicine, Otolaryngology ENT, Upper Airway, Sleep Disorders
Otolaryngology, Pulmonary Medicine
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Diurnal regulation of metabolism by Gs-alpha in hypothalamic QPLOT neurons. PloS one. 2023; 18:e0284824.
Sleep Endoscopy and Cine Magnetic Resonance Imaging Evaluation of Children With Persistent Obstructive Sleep Apnea. Otolaryngology - Head and Neck Surgery. 2023; 168:848-855.
A Word of Caution: Adenotonsillectomy May Help Reduce Central Apneas, but It Is Not a Treatment for Central Sleep Apnea. The Laryngoscope. 2023; 133:E8-E9.
Go to bed!: Sleep as a risk factor for adolescent hypertension. Progress in Pediatric Cardiology. 2023; 68:101613.
Daytime-restricted parenteral feeding is associated with earlier oral intake in children following stem cell transplant. The Journal of Clinical Investigation. 2023; 133:e167275.
Integration of genome-scale data identifies candidate sleep regulators. Sleep. 2023; 46:zsac279.
Expert Consensus Statement: Management of Pediatric Persistent Obstructive Sleep Apnea After Adenotonsillectomy. Otolaryngology - Head and Neck Surgery. 2023; 168:115-130.
167 Earlier Oral Intake in Pediatric Stem Cell Transplant Patients Receiving Time-Restricted Feeding: A Prospective, Randomized Trial. Transplantation and cellular therapy. 2023; 29:s135.
Outcomes of Pre-treatment and Post-treatment measures after therapy for pediatric circadian disorders. Sleep Medicine. 2022; 100:s51-s52.
David F. Smith, MD, PhD, Bala S.C. Koritala, PhD5/30/2023
David F. Smith, MD, PhD, John Hogenesch, PhD10/1/2019