James M. Greenberg, MD

Co-Director, Perinatal Institute

Director, Division of Neonatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3149

Fax 513-803-0968

Email james.greenberg@cchmc.org

Neonatal chronic lung disease; late preterm infant

Dr. Greenberg is a nationally recognized leader in neonatal-perinatal medicine. He serves as director of the Division of Neonatology for Cincinnati Children's Hospital Medical Center leading one of the largest comprehensive clinical and academic programs for newborn care in the United States. Dr. Greenberg has been division director since 2003, and has been an active clinician, researcher and teacher at Cincinnati Children's Hospital Medical Center for more than 22 years. In 2009, he was appointed associate director of the Perinatal Institute at Cincinnati Children’s and became co-director in 2011.

His research activities include developmental biology of the lung, neonatal chronic lung disease, neonatal epidemiology, and prevention of preterm birth. Dr. Greenberg partners with Cincinnati Children's faculty and regional leaders to lead community health initiatives to reduce preterm birth and eliminate infant mortality. He has authored more than 30 original research articles; and six book chapters in the textbook of Pediatrics, Maternal-Fetal Medicine, and Pulmonology.

As medical director for Regional Newborn Services and division director, Dr. Greenberg led the dramatic growth of the neonatology clinical program from 12 faculty physicians providing care at two neonatal intensive care units (NICUs) to more than 50 physicians providing newborn care at 13 regional hospitals including the five NICUs. The Division of Neonatology now has over 120,000 patient encounters per year. In addition to caring for all of the Level III and Level II intensive care nursery patients in the region, division physicians also see more than 18,000 normal newborns every year. The Newborn Intensive Care at Cincinnati Children’s represents the hub of the neonatology clinical program. This NICU has over 750 admissions per year and focuses its activities on caring for infants with complex medical and surgical problems. All patients requiring surgery, surgical subspecialty care, complex radiographic imaging, or comprehensive diagnostic services are managed at the Cincinnati Children's Hospital Medical Center NICU.

In addition to the clinical program, the Division of Neonatology has an active research program. The division is one of the 22 NICHD Neonatal Research Network Centers. Extramural grant funding for the division in fiscal year 2015 was in excess of $10 million. Division research programs span basic, translational, and clinical endeavors.

The division also has an active quality improvement program focusing on outcomes in varied clinical settings ranging from improving reliability of delivery room thermal stability to reduction of central-line-associated blood stream infections in the NICU.

MD: University of Illinois College of Medicine, Chicago, IL, 1977-1981.

Pediatric Internship and Residency: University of Minnesota Hospital and Clinic, Minneapolis, MN, 1981-1984. Chief Resident, Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1984.

Fellowship: Immunology/Neonatology, University of Minnesota Hospital and Clinic, Minneapolis, MN, 1985-1987; 1988-1989; visiting scientist, Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.

Certification: American Board of Pediatrics, 1988; subspecialty board, Neonatal/Perinatal Medicine, 1989.

View PubMed Publications

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.

Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011 Jan-Feb;128(1-2):29-40.

Kulkarni RM, Greenberg JM, Akeson AL. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65.

Mallory BP, Mead TJ, Wiginton DA, Kulkarni RM, Greenberg JM, Akeson AL. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res. 2006 Jul-Sep;72(1-2):62-73.

Preciado DA, Rutter MJ, Greenberg JM, Bahado-Singh R, Lambers D, Willging JP. Intrapartum management of severe fetal airway obstruction. J Otolaryngol. 2004 Oct;33(5):283-8.

Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM. Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res. 2005 Jan;57(1):82-8.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, Akeson AL. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004 Jun;230(2):350-60.

Le Cras TD, Spitzmiller RE, Albertine KH, Greenberg JM, Whitsett JA, Akeson AL. VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L134-42.

Akeson AL, Greenberg JM, Cameron JE, Thompson FY, Brooks SK, Wiginton D, Whitsett JA. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol. 2003 Dec 15;264(2):443-55.

Greenberg JM, Thompson FY, Brooks SK, Shannon JM, McCormick-Shannon K, Cameron JE, Mallory BP, Akeson AL. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn. 2002 Jun;224(2):144-53.