A photo of Richard Lang.

Director, Visual Systems Group

Professor, UC Department of PediatricsUC Department of Ophthalmology

513-636-2700

513-803-0740

Biography & Affiliation

Research Interests

Wnt ligands in tumorigenesis; vascular regression and tissue regeneration; lens induction and morphogenesis.

Academic Affiliation

Professor, UC Department of PediatricsUC Department of Ophthalmology

Divisions

Ophthalmology, Developmental Biology



Blog Posts

Sunlight Reaches Deep Into Brain to Play Key Role in Metabolism

Mind Brain Behavior

Sunlight Reaches Deep Into Brain to Play Key Role in Metabolism

Richard A. Lang, PhD9/2/2020

Our 2019 Research Annual Report

Genomics and Development

Our 2019 Research Annual Report

Richard A. Lang, PhD, John Hogenesch, PhD ...2/4/2020

Fat Cells Can Sense Sunlight. Not Getting Enough Can Disrupt Metabolism

Diabetes and Obesity

Fat Cells Can Sense Sunlight. Not Getting Enough Can Disrupt Metabolism

Richard A. Lang, PhD1/21/2020

Skin Keeps Time Independent of the Brain

Tools for Science

Skin Keeps Time Independent of the Brain

Richard A. Lang, PhD10/17/2019

Light Therapy Might Help Premature Babies Avoid Vision Problems

Rare Diseases

Light Therapy Might Help Premature Babies Avoid Vision Problems

Richard A. Lang, PhD7/3/2019

Education

BSc: Co-major in genetics and biochemistry, University of Melbourne, Australia, 1984 (with honors).

PhD: University of Melbourne, Australia, at the Ludwig Institute for Cancer Research under Drs. AR Dunn and TJ Gonda, 1988.

Postdoctoral Fellow: The G.W. Hooper Research Foundation, University of California, San Francisco under Dr. JM Bishop, 1989-92. Studied the role of the macrophage in developmentally programmed tissue remodeling.

Publications

Selected Publication

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Cell Reports. 2020; 30:672-686.e8.

Neuropsin (OPN5) Mediates Local Light-Dependent Induction of Circadian Clock Genes and Circadian Photoentrainment in Exposed Murine Skin. Buhr, ED; Vemaraju, S; Diaz, N; Lang, RA; Van Gelder, RN. Current Biology. 2019; 29:3478-3487.e4.

An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nguyen, MT; Vemaraju, S; Nayak, G; Odaka, Y; Buhr, ED; Alonzo, N; Tran, U; Batie, M; Upton, BA; Darvas, M; et al. Nature Cell Biology. 2019; 21:420-429.

A direct and melanopsin-dependent fetal light response regulates mouse eye development. Rao, S; Chun, C; Fan, J; Kofron, JM; Yang, MB; Hegde, RS; Ferrara, N; Copenhagen, DR; Lang, RA. Nature. 2013; 494:243-246.

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia. Chauhan, BK; Lou, M; Zheng, Y; Lang, RA. Proceedings of the National Academy of Sciences of USA. 2011; 108:18289-18294.

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. III, SJ A; Lewkowich, I; Rao, S; Mariggi, G; Carpenter, AC; Burr, AR; Fan, J; Ajima, R; Molkentin, JD; Williams, BO; et al. Nature. 2011; 474:511-516.

Macrophage Wnt7b is critical for kidney repair and regeneration. Lin, S; Li, B; Rao, S; Yeo, E; Hudson, TE; Nowlin, BT; Pei, H; Chen, L; Zheng, JJ; Carroll, TJ; et al. Proceedings of the National Academy of Sciences of USA. 2010; 107:4194-4199.

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Lobov, IB; Rao, S; Carroll, TJ; Vallance, JE; Ito, M; Ondr, JK; Kurup, S; Glass, DA; Patel, MS; Shu, WG; et al. Nature. 2005; 437:417-421.

MACROPHAGES ARE REQUIRED FOR CELL-DEATH AND TISSUE REMODELING IN THE DEVELOPING MOUSE EYE. LANG, RA; BISHOP, JM. Cell. 1993; 74:453-462.

TRANSGENIC MICE EXPRESSING A HEMATOPOIETIC GROWTH-FACTOR GENE (GM-CSF) DEVELOP ACCUMULATIONS OF MACROPHAGES, BLINDNESS, AND A FATAL SYNDROME OF TISSUE-DAMAGE. LANG, RA; METCALF, D; CUTHBERTSON, RA; LYONS, I; STANLEY, E; KELSO, A; KANNOURAKIS, G; WILLIAMSON, DJ; KLINTWORTH, GK; GONDA, TJ; et al. Cell. 1988; 53:675-686.