A photo of Theresa Alenghat.

Theresa Alenghat, VMD, PhD


  • Associate Professor, UC Department of Pediatrics

About

BS: Brown University, Providence, RI, 1999.

VMD: University of Pennsylvania, Philadelphia, PA, 2003.

PhD: University of Pennsylvania, Philadelphia, PA, 2007.

Residency: Anatomic Pathology, University of Pennsylvania, Philadelphia, PA.

Certification: Diplomate ACVP, 2011.

Research Areas

Immunobiology, Inflammation and Tolerance

Publications

Selected

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. Eshleman, EM; Shao, TY; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. The Journal of Clinical Investigation. 2023; 133:e162190.

Selected

Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; et al. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Selected

Microbiota-derived metabolite promotes HDAC3 activity in the gut. Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Nature. 2020; 586:108-112.

Selected

Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Immunity. 2020; 52:275-294.e9.

Selected

Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. JCI insight. 2018; 3:e122104.

Selected

Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Gastroenterology. 2018; 155:501-513.

Selected

Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Jiang, TT; Shao, T; Ang, WX G; Kinder, JM; Turner, LH; Pham, G; Whitt, J; Alenghat, T; Way, SS. Cell Host and Microbe. 2017; 22:809-816.e4.

Selected

Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation. Navabi, N; Whitt, J; Wu, S; Woo, V; Moncivaiz, J; Jordan, MB; Vallance, BA; Way, SS; Alenghat, T. Cell Reports. 2017; 19:1165-1175.

Selected

Respiratory epithelial cells orchestrate pulmonary innate immunity. Whitsett, JA; Alenghat, T. Nature Immunology. 2015; 16:27-35.

Selected

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Alenghat, T; Osborne, LC; Saenz, SA; Kobuley, D; Ziegler, CG K; Mullican, SE; Choi, I; Grunberg, S; Sinha, R; Wynosky-Dolfi, M; et al. Nature. 2013; 504:153-157.

From the Blog

Can the Bugs in Our Guts Help Manage Inflammation?
Asthma and Allergy

Can the Bugs in Our Guts Help Manage Inflammation?

Theresa Alenghat, VMD, PhD1/30/2024

Alenghat, Gardner Grace the Stage at TEDx CincinnatiWomen Event
Tools for Science

Alenghat, Gardner Grace the Stage at TEDx CincinnatiWomen Event

Theresa Alenghat, VMD, PhD11/18/2021

Vitamin A Helps Our Immune Systems Thanks in Part to Gut Bacteria That Make Their Own Supply
Infectious Diseases and Vaccines

Vitamin A Helps Our Immune Systems Thanks in Part to Gut Bacteria That Make Their Own Supply

Theresa Alenghat, VMD, PhD10/22/2021

Tissue Healing in the Gut Depends on Help from Friendly Bacteria
Digestive System

Tissue Healing in the Gut Depends on Help from Friendly Bacteria

Theresa Alenghat, VMD, PhD7/30/2020

Our 2019 Research Annual Report
Genomics and Development

Our 2019 Research Annual Report

Theresa Alenghat, VMD, PhD, John Hogenesch, PhD ...2/4/2020