Theresa Alenghat, VMD, PhD

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, H-W; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Immunity. 2024; 57(2):319-332.e6.

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. Eshleman, EM; Shao, T-Y; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Journal of Clinical Investigation. 2023; 133(4).

Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, S-E; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; Vallance, BA; Alenghat, T. Cell Host and Microbe. 2021; 29(12):1744-1756.e5.

Microbiota-derived metabolite promotes HDAC3 activity in the gut. Wu, S-E; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Nature. 2020; 586(7827):108-112.

Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; Zacharias, W; Alenghat, T; Deshmukh, H. Immunity. 2020; 52(2):275-294.e9.

Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; Karns, R; Barski, A; Denson, LA; Alenghat, T. JCI Insight. 2018; 3(18).

Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Gastroenterology. 2018; 155(2):501-513.

Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Jiang, TT; Shao, T-Y; Ang, WXG; Kinder, JM; Turner, LH; Pham, G; Whitt, J; Alenghat, T; Way, SS. Cell Host and Microbe. 2017; 22(6):809-816.e4.

Respiratory epithelial cells orchestrate pulmonary innate immunity. Whitsett, JA; Alenghat, T. Nature Immunology. 2015; 16(1):27-35.

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Alenghat, T; Osborne, LC; Saenz, SA; Kobuley, D; Ziegler, CGK; Mullican, SE; Choi, I; Grunberg, S; Sinha, R; Wynosky-Dolfi, M; Bushman, FD; Won, K-J; Lazar, MA; Artis, D. Nature. 2013; 504(7478):153-157.