Alenghat Lab

Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; et al. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Woo, V; Eshleman, EM; Rice, T; Whitt, J; Vallance, BA; Alenghat, T. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. Frontiers in Immunology. 2019; 10.

Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight. 2018; 3.

Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology. 2018; 155:501-513.

Jiang, TT; Shao, T; Ang, WX G; Kinder, JM; Turner, LH; Pham, G; Whitt, J; Alenghat, T; Way, SS. Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Cell Host and Microbe. 2017; 22:809-816.e4.

Navabi, N; Whitt, J; Wu, S; Woo, V; Moncivaiz, J; Jordan, MB; Vallance, BA; Way, SS; Alenghat, T. Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation. Cell Reports. 2017; 19:1165-1175.

Whitsett, JA; Alenghat, T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nature Immunology. 2015; 16:27-35.

Alenghat, T; Osborne, LC; Saenz, SA; Kobuley, D; Ziegler, CG K; Mullican, SE; Choi, I; Grunberg, S; Sinha, R; Wynosky-Dolfi, M; et al. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 2013; 504:153-157.

Kharofa, J; Apewokin, S; Alenghat, T; Ollberding, NJ. Metagenomic analysis of the fecal microbiome in colorectal cancer patients compared to healthy controls as a function of age. Cancer Medicine. 2022.

Negi, S; Hashimoto-Hill, S; Alenghat, T. Neonatal microbiota-epithelial interactions that impact infection. Frontiers in Microbiology. 2022; 13.

Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; McKinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; et al. Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Gastroenterology. 2022.

Eshleman, E; Shao, T; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells. 2022.

Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; et al. Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Cell Host and Microbe. 2021; 29:1744-1756.e5.

Eshleman, EM; Alenghat, T. Epithelial sensing of microbiota-derived signals. Genes and Immunity. 2021; 22:237-246.

Hashimoto-Hill, S; Alenghat, T. Inflammation-Associated Microbiota Composition Across Domestic Animals. Frontiers in Genetics. 2021; 12.

Woo, V; Eshleman, E; Whitt, J; Hashimoto-Hill, S; Wu, S; Engleman, L; Rice, T; Karns, R; Vallance, B; Alenghat, T. Commensal bacterial-derived retinoic acid primes host defense to intestinal infection. 2021.

Hashimoto-Hill, S; Kelly, DR; Alenghat, T. Chapter 12 Epigenomics of intestinal disease. Medical Epigenetics. 2021.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Almanan, M; Raynor, J; Ogunsulire, I; Malyshkina, A; Mukherjee, S; Hummel, SA; Ingram, JT; Saini, A; Xie, MM; Alenghat, T; et al. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science advances. 2020; 6.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; et al. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52:275-294.e9.

Boucher, AA; Rosenfeldt, L; Mureb, D; Shafer, J; Sharma, BK; Lane, A; Crowther, RR; McKell, MC; Whitt, J; Alenghat, T; et al. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Journal of Thrombosis and Haemostasis. 2020; 18:91-103.

Woo, V; Eshleman, EM; Rice, T; Whitt, J; Vallance, BA; Alenghat, T. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. Frontiers in Immunology. 2019; 10.

Waddell, A; Vallance, JE; Hummel, A; Alenghat, T; Rosen, MJ. IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion. Journal of Immunology. 2019; 202:598-607.

Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight. 2018; 3.

Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology. 2018; 155:501-513.