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High Res

Michael A. Helmrath, MD, MS

Surgical Director, Intestinal Rehabilitation Program

Director of Surgical Research

Professor, UC Department of Surgery

Phone: 513-636-4371

Email: michael.helmrath@cchmc.org

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Biography

As a pediatric surgeon, Dr. Helmrath has dedicated his career to the care of patients with intestinal failure. The main focus of his laboratory is directed towards characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his clinical experience as the surgical director of intestinal research and rehabilitation at Cincinnati Children’s Hospital, his long-term goal is to establish translational therapies for the management of patients with short bowel syndrome.

Education and Training

BA: Miami University, Oxford, OH, 1987.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.

MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.

Publications

View PubMed Publications

Helmrath MA, Shin CE, Fox JW, Erwin CR, Warner BW. Adaptation after small bowel resection is attenuated by sialoadenectomy: The role for endogenous epidermal growth factor. Surgery. 1998;124 (5):848-854.

Erwin CR, Helmrath MA, Shin CE, Falcone RA Jr., Stern LE, Warner BW. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol Gastrointest Liver Physiol. 1999;277:G533-G540.

Helmrath MA, Fong JJ, Dekaney CM, Henning SJ. Rapid expansion of intestinal secretory lineages following a massive small bowel resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;292(1): G215-222.

Shroyer NF, Helmrath MA, Wang YYC, Antalffy B, Henning SJ, Zoghbi HY. Intestine specific ablation of Math 1 in mice reveals a role in cellular homeostasis. Gastroenterology. 2007;132(7):2478-2488.

Dekaney CM, Fong JJ, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007;293(5): G1013-22.

Dekaney CM, von Allmen DC, Garrison AP, Rigby RJ, Lund PK, Henning SJ, Helmrath MA. Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileocecal resection. Surgery. 2008;144(2):174-81.

Garrison AP, Dekaney CM, von Allmen DC, Lund PK, Henning SJ, Helmrath MA. Early but not late administration of glucagons-like peptide-2 following ileocecal resection augments putative intestinal stem cell expansion. Am J Physiol Liver Physiol. 2009;296(3): G643-50.

Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA, Lund PK. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora. Gut. 2009;58(8);1104-12.

Garrison AP, Helmrath MA, Dekaney CM. Intestinal Stem Cells. J Pediatr Gastroenterol Nutr. 2009;49(1):2-7.

Speck KE, Garrison AP, Rigby RJ, von Allmen DC, Lund PK, Helmrath MA. Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Research. 2011;168(1):62-69.

Grants

Mechanisms of intestinal stem cell expansion following resection. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Disease. Jul 2009 - June 2014. #R01DK083325.

Collaborative approach to the study of intestinal epithelial stem cells. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2009 - Aug 2014. #1U01DK085547.

Neointestine from live donors & pluripotent stem cells. Co-investigator. CCST University of Cincinnati. 07/01/11 – 06/30/11.

Adolescent Bariatrics: Assessing Health Benefits & Risk. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 11/01/11 – 10/31/16. U01 DK072493.

Human Endocrine Cell Development. Co-investigator. National Institute of Diabetes and Digestive and Kidney Diseases. 04/01/12 – 03/31/17. R01 DK092456.