James M. Wells, PhD
- Director for Research, Division of Endocrinology
- Chief Scientific Office, Center for Stem Cell and Organoid Medicine (CuSTOM)
- Professor, UC Department of Pediatrics
About
Biography
The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.
BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.
PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.
Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001.
Interests
Understanding the development of the pancreas, and gastrointestinal organs; generating 3-dimensional human tissues from pluripotent stem cells and using these as human models of diabetes and digestive disease.
For more information, please visit the CuSTOM web page.
Research Areas
Endocrinology, Developmental Biology
Publications
Ontogeny and function of the circadian clock in intestinal organoids. EMBO Journal. 2022; 41.
A dietary change to a high-fat diet initiates a rapid adaptation of the intestine. Cell Reports. 2022; 41.
Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. 2022; 28:988-1003.
Enteroendocrine cell differentiation and function in the intestine. Current Opinion in Endocrinology, Diabetes and Obesity. 2022; 29:169-176.
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.
Developmental basis of trachea-esophageal birth defects. Developmental Biology. 2021; 477:85-97.
Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis. Frontiers in Pediatrics. 2021; 9.
Application of Interacting Multiple Model for Future State Prediction of Small Unmanned Aerial Systems. (2021) 00:3755-3760.
Engineering-inspired approaches to study β-cell function and diabetes. Stem Cells. 2021; 39:522-535.
Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes. DMM Disease Models and Mechanisms. 2021; 14.
From the Blog
Novel Approach Generates Most Complex Stomach, Esophagus Organoids to Date
James M. Wells, PhD, Michael A. Helmrath, MD ...2/8/2023
New Assembly Approach Generates Most Complex Stomach Organoids to Date
James M. Wells, PhD12/1/2021
Organoid Expert James Wells, PhD, Joins Journal as Academic Editor
James M. Wells, PhD7/12/2021
World’s First Three-Organoid System Opens Doors for Medical Research and Diagnosis
James M. Wells, PhD, Takanori Takebe, MD, PhD ...3/22/2021
Paul G. Allen Frontiers Group Names Cincinnati Children’s Scientist an Allen Distinguished Investigator
James M. Wells, PhD11/6/2019
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