Takanori Takebe, MD


Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Associate Professor, Department of Regenerative Medicine, Yokohama City University, Japan

Phone 513-803-7807

Fax 513-636-5581

Email takanori.takebe@cchmc.org

Clinical

Hepatology; transplantation

Research

Organoid; organogenesis; stem cell biology; transplantation; drug development

Visit the Takebe Lab and Visit the Takebe Lab at Cincinnati Children's Hospital Medical Center.

Dr. Takebe is an assistant professor at the Cincinnati Children’s Hospital Medical Center. His lab is developing and applying mini-organ technologies from human stem cells – namely organ bud transplants – in patients with a rare congenital metabolic disorder, ultimately expanding the clinical applications to diseases like liver cirrhosis. Also, he holds a joint appointment at the Department of Regenerative Medicine, Yokohama City University in Japan, where he directs a translational program of human induced pluripotent stem cell (iPSC) based liver bud based approach for congenital liver disorders by developing a cGMP manufacturing platform.

Dr. Takebe successfully administered more than six nationally funded projects, awarded number of prestigious awards such as NYSCF robertson investigator award, and produced high impact peer-reviewed publications from each project. His recent associate professor appointment, at the age 26, was one of the youngest recorded in Japan.

MD: Yokohama City University, Japan, 2011.

View PubMed Publications

Shinozawa T, Yoshikawa H-Y, Takebe T*. Reverse Engineering Organ Buds through Self-Driven Condensation and Organization. Developmental Biology. 2016 Jun 27. (*Correspondence)

Takahashi Y, Takebe T*, Taniguchi H*. Engineering pancreatic tissues from stem cells towards therapy. Regenerative Therapy. 2016(3):15-23. (*Joint corresponding authors)

Kagimoto S, Takebe T*, Kobayashi S, Yabuki Y, Hori A, Hirotomi K, Mikami T, Uemura T, Maegawa J, Taniguchi H. Autotransplantation of monkey ear perichondrium-derived progenitor cells for cartilage reconstruction. Cell transplantation. 2016;25(5):951-62. (*Joint corresponding authors)

Takebe T*, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa H-Y, Taniguchi H. Vascularized And Complex Organ Buds From Diverse Tissues Via Mesenchymal Cell-Driven Condensation. Cell Stem Cell. 2015 Apr;16(5):556-565. (*Corresponding author, Selected as Cover Work)

  • Selected as Cover Work 
  • Selected as Best of Cell Stem Cell 
  • Previewed in Cell Stem Cell
  • Featured in Nature Method

Rashid T, Takebe T, Nakauchi H. Novel strategies for liver therapy using stem cells. Gut. 2015;64:1-4.

Zhang RR, Koike H, Takebe T. The visualization of human organogenesis from stem cells by recapitulating multicellular interactions. In Hyper Bio Assembler for 3D Cellular Systems. 2015:275-283.

Takebe T *, Kobayashi S, Suzuki H, Mizuno M, Chang YM, Yoshizawa E, Kimura M, Hori A, Asano J, Maegawa J, Taniguchi H. Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage. Journal of Clinical Investigation. 2014 Oct;124(10):4325-34. (*Corresponding author)

Takebe T*, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, Sekine K, Taniguchi H*. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature Protocols. 2014;9:396–409. (*Corresponding author)

Koike H, Ueno Y, Naito T, Shiina T, Ouchi R, Obana Y, Mori M, Sekine K, Takebe T, Zheng YW, Isono K, Koseki H, Taniguchi H. Ring1B Promotes Hepatic Stem/Progenitor Cell Expansion via Simultaneous Suppression of Cdkn1a and Cdkn2a. Hepatology. 2014 Jul;60(1):323-33.

Takebe T*, Sekine K, Enomura M, Koike H, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguch H*: Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;499:481–484. (*Corresponding author) 

  • Selected as Science Breakthrough of the Year
  • Selected as Word Top5 discovery, Discover Magazine
  • Featured in Nature, Nature Medicine, Cell Stem Cell, Gastroenterology, Hepatology, Cell Research
  • Featured in The Economist, New Scientist magazine, Newton, etc

Robertson Investigator Award. Principal Investigator. New-York Stem Cell Foundation. Jan 2017-Dec 2021. 

In vitro human organ generation by reconstituting spatiotemporal control of multiple cellular interactions. Principal Investigator. PRESTO, JST. Oct 2013-Mar 2017.