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A photo of Takanori Takebe.

Assistant Professor, UC Department of PediatricsAssociate Professor, Department of Regenerative Medicine, Yokohama City University, Japan

513-803-7807

513-636-5581

My Biography & Research

Biography

Dr. Takebe is an assistant professor at the Cincinnati Children’s Hospital Medical Center. His lab is developing and applying mini-organ technologies from human stem cells – namely organ bud transplants – in patients with a rare congenital metabolic disorder, ultimately expanding the clinical applications to diseases like liver cirrhosis. Also, he holds a joint appointment at the Department of Regenerative Medicine, Yokohama City University in Japan, where he directs a translational program of human induced pluripotent stem cell (iPSC) based liver bud based approach for congenital liver disorders by developing a cGMP manufacturing platform.

Dr. Takebe successfully administered more than six nationally funded projects, awarded number of prestigious awards such as NYSCF robertson investigator award, and produced high impact peer-reviewed publications from each project. His recent associate professor appointment, at the age 26, was one of the youngest recorded in Japan.

Clinical Interests

Hepatology; transplantation

Research Interests

Organoid; organogenesis; stem cell biology; transplantation; drug development

Visit the Takebe Lab.

Academic Affiliation

Assistant Professor, UC Department of PediatricsAssociate Professor, Department of Regenerative Medicine, Yokohama City University, Japan

Departments

Gastroenterology GI, Gastroenterology, Developmental Biology

My Education

MD: Yokohama City University, Japan, 2011.

My Publications

De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo. Fang, H; Yao, S; Chen, Q; Liu, C; Cai, Y; Geng, S; Bai, Y; Tian, Z; Zacharias, AL; Takebe, T; et al. ACS Nano. 2019; 13:14426-14436.

The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Liu, T; Zhou, L; Yang, K; Iwasawa, K; Kadekaro, AL; Takebe, T; Andl, T; Zhang, Y. Signal Transduction and Targeted Therapy. 2019; 4.

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Nature. 2019; 574:112-116.

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Cell Metabolism. 2019; 30:374-384.e6.

Organoids by design. Takebe, T; Wells, JM. Science. 2019; 364:956-959.

Approach for Communication Design for Motivation to Health Behavior. Iizuka, S; Takebe, T; Nishii, S; Kodaka, A. (2019) Springer International Publishing. 11569 LNCS:425-436.

Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics. Matsuzaki, T; Matsumoto, S; Kasai, T; Yoshizawa, E; Okamoto, S; Yoshikawa, HY; Taniguchi, H; Takebe, T. Stem Cell Reports. 2018; 11:852-860.

Tumoroid a la carte: Path for personalization. Lewis, K; Takebe, T. Hepatology. 2018; 68:1189-1191.

Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. Nie, Y; Zheng, Y; Miyakawa, K; Murata, S; Zhang, R; Sekine, K; Ueno, Y; Takebe, T; Wakita, T; Ryo, A; et al. EBioMedicine. 2018; 35:114-123.

Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling. Ayabe, H; Anada, T; Kamoya, T; Sato, T; Kimura, M; Yoshizawa, E; Kikuchi, S; Ueno, Y; Sekine, K; Camp, JG; et al. Stem Cell Reports. 2018; 11:306-316.