Takebe Lab

Han, L; Chaturvedi, P; Kishimoto, K; Koike, H; Nasr, T; Iwasawa, K; Giesbrecht, K; Witcher, PC; Eicher, A; Haines, L; et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature Communications. 2020; 11.

Sekine, K; Ogawa, S; Tsuzuki, S; Ikeda, K; Nakanishi, N; Takeuchi, K; Kanai, E; Otake, Y; Okamoto, S; Kobayashi, T; et al. Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media. Scientific Reports. 2020; 10.

Koido, M; Kawakami, E; Fukumura, J; Noguchi, Y; Ohori, M; Nio, Y; Nicoletti, P; Aithal, GP; Daly, AK; Watkins, PB; et al. Polygenic architecture informs potential vulnerability to drug-induced liver injury. Nature Medicine. 2020; 26:1541-1548.

Okabe, R; Chen-Yoshikawa, TF; Yoshizawa, A; Hirashima, T; Saito, M; Date, H; Takebe, T. Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice. European Journal of Cardio-Thoracic Surgery. 2020; 58:638-645.

Kobayashi, N; Togo, S; Matsuzaki, T; Hashiseko, K; Kawamura, R; Suganuma, M; Nakabayashi, S; Yoneyama, Y; Ouchi, R; Takebe, T; et al. Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM. Applied Physics Express. 2020; 13:097001-097001.

Sakabe, K; Takebe, T; Asai, A. Organoid Medicine in Hepatology. Clinical Liver Disease. 2020; 15:3-8.

Thompson, WL; Takebe, T. Generation of multi-cellular human liver organoids from pluripotent stem cells. Methods in Cell Biology. : Elsevier; Elsevier; 2020.

Iizuka, S; Nishii, S; Tanimoto, E; Nakazawa, H; Kodaka, A; Takebe, T. (2020) Waiting time analysis at university hospitals based on visitor psychology. Springer International Publishing. 12184 LNCS:212-221.

Fang, H; Yao, S; Chen, Q; Liu, C; Cai, Y; Geng, S; Bai, Y; Tian, Z; Zacharias, AL; Takebe, T; et al. De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo. ACS Nano. 2019; 13:14426-14436.

Liu, T; Zhou, L; Yang, K; Iwasawa, K; Kadekaro, AL; Takebe, T; Andl, T; Zhang, Y. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduction and Targeted Therapy. 2019; 4.

Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature. 2019; 574:112-116.

Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metabolism. 2019; 30:374-384.e6.

Takebe, T; Wells, JM. Organoids by design. Science. 2019; 364:956-959.

Iizuka, S; Takebe, T; Nishii, S; Kodaka, A. (2019) Approach for Communication Design for Motivation to Health Behavior. Springer International Publishing. 11569 LNCS:425-436.

Matsuzaki, T; Matsumoto, S; Kasai, T; Yoshizawa, E; Okamoto, S; Yoshikawa, HY; Taniguchi, H; Takebe, T. Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics. Stem Cell Reports. 2018; 11:852-860.

Lewis, K; Takebe, T. Tumoroid a la carte: Path for personalization. Hepatology. 2018; 68:1189-1191.

Nie, Y; Zheng, Y; Miyakawa, K; Murata, S; Zhang, R; Sekine, K; Ueno, Y; Takebe, T; Wakita, T; Ryo, A; et al. Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells. EBioMedicine. 2018; 35:114-123.

Ayabe, H; Anada, T; Kamoya, T; Sato, T; Kimura, M; Yoshizawa, E; Kikuchi, S; Ueno, Y; Sekine, K; Camp, JG; et al. Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling. Stem Cell Reports. 2018; 11:306-316.

Kimura, M; Azuma, M; Zhang, R; Thompson, W; Mayhew, CN; Takebe, T. Digitalized Human Organoid for Wireless Phenotyping. iScience. 2018; 4:294-301.

Rao, MS; Pei, Y; Garcia, TY; Chew, S; Kasai, T; Hisai, T; Taniguchi, H; Takebe, T; Lamba, DA; Zeng, X. Illustrating the potency of current Good Manufacturing Practice-compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols. Cytotherapy (Informa). 2018; 20:861-872.

Takebe, T; Wells, JM; Helmrath, MA; Zorn, AM. Organoid Center Strategies for Accelerating Clinical Translation. Cell Stem Cell. 2018; 22:806-809.

Takahashi, Y; Sekine, K; Kin, T; Takebe, T; Taniguchi, H. Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation. Cell Reports. 2018; 23:1620-1629.

Takahashi, Y; Takebe, T; Taniguchi, H. Methods for Generating Vascularized Islet-Like Organoids Via Self-Condensation. Current Protocols in Stem Cell Biology. 2018; 45:e49-e49.

Zhang, R; Koido, M; Tadokoro, T; Ouchi, R; Matsuno, T; Ueno, Y; Sekine, K; Takebe, T; Taniguchi, H. Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids. Stem Cell Reports. 2018; 10:780-793.

Takebe, T; Sekine, K; Kimura, M; Yoshizawa, E; Ayano, S; Koido, M; Funayama, S; Nakanishi, N; Hisai, T; Kobayashi, T; et al. Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells. Cell Reports. 2017; 21:2661-2670.

Takebe, T; Zhang, B; Radisic, M. Synergistic Engineering: Organoids Meet Organs-on-a-Chip. Cell Stem Cell. 2017; 21:297-300.

Takebe, T; Sekine, K; Camp, G; Treutlein, B. Human Liver Bud Organoid Models Development. Cell Systems. 2017; 5:2-2.

Camp, JG; Sekine, K; Gerber, T; Loeffler-Wirth, H; Binder, H; Gac, M; Kanton, S; Kageyama, J; Damm, G; Seehofer, D; et al. Multilineage communication regulates human liver bud development from pluripotency. Nature. 2017; 546:533-538.

Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Development (Cambridge). 2017; 144:1056-1064.

Koike, H; Zhang, R; Ueno, Y; Sekine, K; Zheng, Y; Takebe, T; Taniguchi, H. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development (Cambridge). 2017; 144:1018-1024.

Ito, K; Sakuma, S; Kimura, M; Takebe, T; Kaneko, M; Arai, F; IEEE, . (2017) Mechanical characterization system using on-chip probe with wide range actuation. IEEE.

Sekine, K; Takebe, T; Taniguchi, H. Liver regeneration using cultured liver bud. Methods in molecular biology (Clifton, N.J.). 2017; 1597:207-216.

Sekine, K; Takebe, T; Taniguchi, H. Liver regeneration using cultured liver bud. Organ Regeneration Based on Developmental Biology. : Springer Singapore; Springer Singapore; 2017.

Shinozawa, T; Yoshikawa, HY; Takebe, T. Reverse engineering liver buds through self-driven condensation and organization towards medical application. Developmental Biology. 2016; 420:221-229.

Ito, K; Sakuma, S; Kimura, M; Takebe, T; Kaneko, M; Arai, F. Temporal Transition of Mechanical Characteristics of HUVEC/MSC Spheroids Using a Microfluidic Chip with Force Sensor Probes. Micromachines. 2016; 7:221-221.

Koike, H; Rashid, T; Takebe, T. Growing Mini-Organs from Stem Cells. In: Meyers RA, Ed. Reviews in Cell Biology and Molecular Medicine. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA; 2016.

Koike, H; Takebe, T. Generating Mini-Organs in Culture. Current Pathobiology Reports. 2016; 4:59-68.

Kagimoto, S; Takebe, T; KobayashiA, S; Yabukig, Y; Hori, A; Hirotomi, K; Mikami, T; Uemura, T; Maegawa, J; Taniguchi, H. Autotransplantation of Monkey Ear Perichondrium-Derived Progenitor Cells for Cartilage Reconstruction. Cell Transplantation. 2016; 25:951-962.

Takahashi, Y; Takebe, T; Taniguchi, H. Engineering pancreatic tissues from stem cells towards therapy. Regenerative Therapy. 2016; 3:15-23.

Ito, K; Sakuma, S; Kimura, M; Takebe, T; Kaneko, M; Arai, F; IEEE, . (2016) STIFFNESS-INDEX MAP BASED ON SINGLE CELL-SPHEROID ANALYSIS USING ROBOT INTEGRATED MICROFLUIDIC CHIIP. IEEE. 2016-February:157-160.