Takebe Lab

Publications

Glaser, K; Depasquale, EAK; Berklite, L; Hickner, BT; Rao, P; Patel, RH; Badachhape, AA; Roy, S; Schepers, E; Timchenko, NA; Takebe, T; Woodfield, SE; Vasudevan, SA; Bondoc, AJ. Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma. Scientific Reports. 2026.

Yamaguchi, H; Yoneyama, Y; Ichimura, K; Ohtsu, K; Soen, M; Moriya, C; Kumagai, M; Myers, RP; Subramanian, GM; Takebe, T. Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis. Journal of Hepatology. 2026; 84(2):293-307.

Li, X; Benegiamo, G; Vijayakumar, A; Sroda, N; Kimura, M; Huss, RS; Weng, S; Murakami, E; Kirby, BJ; Von Alvensleben, GVG; Takebe, T; Myers, RP; Subramanian, GM; Auwerx, J. An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial. Nature Medicine. 2026.

Hirai, A; Yoneyama, Y; Assi, I; Osonoi, S; Sakai, S; Ohtsu, K; Takebe, T. Modeling Transmembrane 6 Superfamily Member 2 p.Glu167Lys-associated Steatotic Liver Disease Using Androgen-treated Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells. Gastro Hep Advances. 2026; 5(1):100774.

Wu, Y; Wang, L; Lu, Z; Oda, M; Hayashi, Y; Kawamura, S; Takebe, T; Mori, K. Domain-Specific Pretraining and Fine-Tuning with Contrastive Learning for Fluorescence Microscopic Image Segmentation. In: Applications of Medical Artificial Intelligence. Springer Nature; 2026:278-288.

Rezvani, M; Quach, S; Lewis, K; Saiki, N; Xue, C; Kimura, M; Iwasawa, K; Weihs, J; Elzobair, T; Al Reza, H; Zorn, A; Wells, JM; Yoshimoto, M; Takebe, T. Modeling Immune Lineage Co-Development in Human Pluripotent Stem Cell-derived Liver Organoids. Journal of Hepatology. 2025.

Fujii, T; Kurihara, Y; Tagawa, Y; Nagai, H; Yokota, C; Mizuo, H; Takebe, T. Safety and tolerability of intrarectal perfluorodecalin for enteral ventilation in a first-in-human trial. Med. 2025; 6(12):100887.

Kawamura, S; Yoneyama, Y; Saiki, N; Wu, Y; Moriya, C; Ohmura, R; Maezawa, M; Shimada, Y; Wang, Y; Mori, K; Sanada, Y; Hirata, Y; Sakuma, Y; Takebe, T. Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids. Cell Reports Medicine. 2025; 6(11):102433.

Saiki, N; Nio, Y; Yoneyama, Y; Kawamura, S; Iwasawa, K; Kawakami, E; Araki, K; Fukumura, J; Sakairi, T; Kono, T; Thompson, WL; Cruz-Encarnacion, P; Chen, Y-W; Takebe, T. Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids. Nature Biomedical Engineering. 2025; 9(11):1869-1885.

Soussi, FEA; Brusilovsky, M; Buck, E; Bacon, WC; Dadgar, S; Fullerton, A; Durban, VM; Barrile, R; Helmrath, MA; Takebe, T; Roth, A; Kasendra, M. Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury. Advanced Science. 2025; 12(43):e08584.

Miao, Y; Pek, NM; Tan, C; Jiang, C; Yu, Z; Iwasawa, K; Shi, M; Kechele, DO; Sundaram, N; Pastrana-Gomez, V; Zorn, AM; Chen, Y-W; Guo, M; Gu, M. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025; 188(16):4295-4313.e27.

Krutko, M; Poling, HM; Sheth, M; Kongsomros, S; Bryan, AE; Sharma, M; Singh, A; Reza, HA; Wikenheiser-Brokamp, KA; Takebe, T; Helmrath, MA; Harris, GM; Esfandiari, L. Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF-TrFE Nanofiber Scaffolds. Advanced Materials Technologies. 2025.

Fukunaga, I; Takebe, T. In vitro liver models for toxicological research. Drug Metabolism and Pharmacokinetics. 2025; 62:101478.

Kinoshita, Y; Kobayashi, E; Matsui, K; Inage, Y; Morimoto, K; Yamamoto, S; Iwai, S; Kitada, K; Iwasawa, K; Saito, Y; Kume, H; Takebe, T; Yokoo, T; Yamanaka, S. Life-supporting functional kidney replacement by integration of embryonic metanephros-bladder composite tissue transplants. Kidney International. 2025; 107(6):1051-1063.

Reza, HA; Santangelo, C; Iwasawa, K; Reza, AA; Sekiya, S; Glaser, K; Bondoc, A; Merola, J; Takebe, T. Multi-zonal liver organoids from human pluripotent stem cells. Nature. 2025; 641(8065):1258-1267.

Ashmore-Harris, C; Ayabe, H; Yoshizawa, E; Arisawa, T; Takada, Y; Takebe, T; Fruhwirth, GO. Gene editing enables non-invasive in vivo PET imaging of human induced pluripotent stem cell-derived liver bud organoids. Molecular Therapy: Methods & Clinical Development. 2025; 33(1):101406.

Jurickova, I; Dreskin, BW; Angerman, E; Bonkowski, E; Nguyen, J; Villarreal, R; Tominaga, K; Iwasawa, K; Braun, T; Takebe, T; Helmrath, MA; Haberman, Y; Wells, JM; Denson, LA. Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease. Journal of Crohn's and Colitis. 2025; 19(2).

Liu, YJ; Kimura, M; Li, X; Sulc, J; Wang, Q; Rodríguez-López, S; Scantlebery, AML; Strotjohann, K; Gallart-Ayala, H; Vijayakumar, A; Houtkooper, RH; Subramanian, GM; Takebe, T; Auwerx, J. ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH. Journal of Hepatology. 2025; 82(2):174-188.

Yoneyama, Y; Zhang, R-R; Maezawa, M; Masaki, H; Kimura, M; Cai, Y; Adam, M; Parameswaran, S; Mizuno, N; Bhadury, J; Nakauchi, H; Potter, SS; Weirauch, MT; Takebe, T. Intercellular mRNA transfer alters the human pluripotent stem cell state. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(4):e2413351122.

Murata, N; Nishii, S; Usuha, R; Kodaka, A; Fujimori, M; Sugawara, H; Kiriyama, T; Uchikado, H; Okumura, Y; Takebe, T. A Gamified N-back App for Identifying Mild-cognitive Impairment in Older Adults. JMA J. 2025; 8(1):174-182.

Yoneyama, Y; Wu, Y; Mori, K; Takebe, T. In toto biological framework: Modeling interconnectedness during human development. Developmental Cell. 2025; 60(1):8-20.

Tominaga, K; Kechele, DO; Sanchez, JG; Vales, S; Jurickova, I; Roman, L; Asai, A; Enriquez, JR; Mccauley, HA; Kishimoto, K; Zorn, AM; Helmrath, MA; Denson, LA; Wells, JM. Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells. Cellular and Molecular Gastroenterology and Hepatology (CMGH). 2025; 19(4):101444.

Wu, Y; Menten, MJ; Kreitner, L; Kawamura, S; Oda, M; Hayashi, Y; Takebe, T; Rueckert, D; Mori, K. CLSMI2T3: 3D CLSM Vasculature Volume Reconstruction from A Single 2D Slice by Off-Focal Plane Signal Using Synthetic Data. In: Medical Optical Imaging and Virtual Microscopy Image Analysis. Springer Nature; 2025:108-118.

Wu, Y; Pan, J; Kawamura, S; Oda, M; Hayashi, Y; Takebe, T; Rueckert, D; Mori, K. A Deployable Microscopic Image Segmentation Look-Up Table Based on A Dilated CNN. In: Medical Optical Imaging and Virtual Microscopy Image Analysis. Springer Nature; 2025:3-13.

Lutolf, MP; Radisic, M; Beekman, J; Huh, DD; Huch, M; Turco, MY; Birgani, ZNT; Gao, D; Yao, R; Lin, H; Takebe, T. In vitro human cell-based models: What can they do and what are their limitations? Trends in Biotechnology. 2024; 42(12):1577-1582.

Poling, HM; Sundaram, N; Fisher, GW; Singh, A; Shiley, JR; Nattamai, K; Govindarajah, V; Cortez, AR; Krutko, MO; Ménoret, S; Mayhew, CN; Takebe, T; Mahe, MM; Helmrath, MA. Human pluripotent stem cell-derived organoids repair damaged bowel in vivo. Cell Stem Cell. 2024; 31(10):1513-1523.e7.

Sheth, M; Sharma, M; Lehn, M; Reza, H; Takebe, T; Takiar, V; Wise-Draper, T; Esfandiari, L. Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids. APL Bioengineering. 2024; 8(3):036106.

Kang, S-Y; Kimura, M; Shrestha, S; Lewis, P; Lee, S; Cai, Y; Joshi, P; Acharya, P; Liu, J; Yang, Y; Alsberg, E; Wells, JM; Takebe, T; Lee, M-Y. A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis. Advanced healthcare materials. 2024; 13(21):e2302502.

Kimura, M; Takebe, T. Cellotype-phenotype associations using 'organoid villages'. Trends in Endocrinology and Metabolism. 2024; 35(6):462-465.

Nishimura, T; Takebe, T. Synthetic human gonadal tissues for toxicology. Reproductive Toxicology. 2024; 126:108598.

Osonoi, S; Takebe, T. Organoid-guided precision hepatology for metabolic liver disease. Journal of Hepatology. 2024; 80(5):805-821.

Naraoka, Y; Mabuchi, Y; Kiuchi, M; Kumagai, K; Hisamatsu, D; Yoneyama, Y; Takebe, T; Akazawa, C. Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities. Cells. 2024; 13(2).

Reza, HA; Farooqui, Z; Reza, AA; Conroy, C; Iwasawa, K; Ogura, Y; Okita, K; Osafune, K; Takebe, T. Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids. Stem Cell Reports. 2023; 18(11):2071-2083.

Múnera, JO; Kechele, DO; Bouffi, C; Qu, N; Jing, R; Maity, P; Enriquez, JR; Han, L; Campbell, I; Mahe, MM; Hu, Y-C; Takebe, T; Helmrath, MA; Wells, JM. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023; 30(11):1434-1451.e9.

Kawakami, E; Saiki, N; Yoneyama, Y; Moriya, C; Maezawa, M; Kawamura, S; Kinebuchi, A; Kono, T; Funata, M; Sakoda, A; Itoh, Y; Takayama, K; Nio, Y; Takebe, T. Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19. Cell Stem Cell. 2023; 30(10):1315-1330.e10.

Matsuzaki, T; Kawano, Y; Horikiri, M; Shimokawa, Y; Yamazaki, T; Okuma, N; Koike, H; Kimura, M; Kawamura, R; Yoneyama, Y; Nakauchi, H; Taniguchi, H; Takebe, T; Yoshikawa, HY. Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells. STAR Protocols. 2023; 4(3):102471.

Tamaoki, N; Siebert, S; Maeda, T; Ha, N-H; Good, ML; Huang, Y; Vodnala, SK; Haro-Mora, JJ; Uchida, N; Tisdale, JF; Robey, PG; Kruhlak, MJ; Restifo, NP; Vizcardo, R. Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells. Cell Reports: Methods. 2023; 3(4):100460.

Fujii, T; Yoneyama, Y; Kinebuchi, A; Ozeki, N; Maeda, S; Saiki, N; Chen-Yoshikawa, TF; Date, H; Nishiwaki, K; Takebe, T. Enteral liquid ventilation oxygenates a hypoxic pig model. iScience. 2023; 26(3):106142.

Kishimoto, K; Iwasawa, K; Sorel, A; Ferran-Heredia, C; Han, L; Morimoto, M; Wells, JM; Takebe, T; Zorn, AM. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nature Protocols. 2022; 17(11):2699-2719.

Kimura, M; Iguchi, T; Iwasawa, K; Dunn, A; Thompson, WL; Yoneyama, Y; Chaturvedi, P; Zorn, AM; Wintzinger, M; Quattrocelli, M; Myers, RP; Subramanian, GM; Hwa, V; Takebe, T. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Cell. 2022; 185(22):4216-4232.e16.

Matsuzaki, T; Shimokawa, Y; Koike, H; Kimura, M; Kawano, Y; Okuma, N; Kawamura, R; Yoneyama, Y; Furuichi, Y; Hakuno, F; Nakauchi, H; Taniguchi, H; Takebe, T; Yoshikawa, HY. Mechanical guidance of self-condensation patterns of differentiating progeny. iScience. 2022; 25(10):105109.

Lee, IS; Takebe, T. Narrative engineering of the liver. Current Opinion in Genetics and Development. 2022; 75:101925.

Jurickova, I; Bonkowski, E; Angerman, E; Novak, E; Huron, A; Akers, G; Iwasawa, K; Braun, T; Hadar, R; Hooker, M; Takebe, T; Mollen, KP; Haberman, Y; Denson, LA. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. 2022; 28(7):988-1003.

Mizuno, M; Matsuzaki, T; Ozeki, N; Katano, H; Koga, H; Takebe, T; Yoshikawa, HY; Sekiya, I. Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. Stem Cell Research and Therapy. 2022; 13(1):177.

Lansing, F; Mukhametzyanova, L; Rojo-Romanos, T; Iwasawa, K; Kimura, M; Paszkowski-Rogacz, M; Karpinski, J; Grass, T; Sonntag, J; Schneider, PM; Rodriguez-Muela, N; Knöfler, R; Takebe, T; Buchholz, F. Correction of a Factor VIII genomic inversion with designer-recombinases. Nature Communications. 2022; 13(1):422.