Michael A. Helmrath, MD

Surgical Director, Intestinal Rehabilitation Program

Director of Surgical Research
Associate Director of Clinical Translation, CuSTOM
Director, Center for Bariatric Research and Innovation
Pediatric Surgeon

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-636-4371

Email michael.helmrath@cchmc.org

Research InterestsHide

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BiographyHide

As a pediatric surgeon scientist, Dr. Helmrath has established a large multidisciplinary team dedicated to clinical, translational, and basic science research focused on human diseases. Clinically, he is dedicated to patients with intestinal diseases and obesity. In his laboratory he focuses on characterizing intestinal stem cells during intestinal adaptation and developing intestinal regenerative strategies. By combining his current roles as director of Surgical Research, director for the Center for Bariatric Research and Innovation, surgical director of the Intestinal Rehabilitation Program, and associate director of Clinical Translation for CuSTOM, his strong basic science research background further allows him to translate human GI conditions to the laboratory to develop highly innovative approaches to treat intestinal diseases.

Education and TrainingHide

BA: Miami University, Oxford, OH, 1987.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1993.

MS: University of Cincinnati College of Medicine, Cincinnati, OH, 1989.

Certification: Board-certified General Surgery; board-certified, Pediatric Surgery.

PublicationsHide

View PubMed Publications

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM. Mechanically induced development and maturation of human intestinal organoids in vivo. Nat Biomed Eng. 2018 Jun;2(6):429-442.

Takebe T, Wells JM, Helmrath MA, Zorn AM. Organoid Center Strategies for Accelerating Clinical Translation. Cell Stem Cell. 2018 Jun 1;22(6):806-809.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med. 2017 Jan;23(1):49-59.

Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen-LABS Consortium. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. N Engl J Med. 2016 Jan 14;374(2):113-23.

GrantsHide

Limited Competition for the Continuation of Teen-LABS (Adolescent Longitudinal Assessment of Bariatric Surgery) Clinical Centers (Collaborative U01). Co-Investigator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2016-Aug 2021. UM1DK072493.

Patient Centered Outcomes. Co-Investigator. Research Institute (PCORI). Aug 2016-Oct 2019.

The Role of Hedgehog Signaling in gastric tissue repair and regeneration. Collaborator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases. Jul 2016-Apr 2020. R01DK083402.

LPA2 receptor-containing complexes in regulating secretory diarrhea. Co-Investigator. National Institute of Diabetes and Digestive and Kidney Diseases. Jul 2015-Jun 2020. R01DK093045.

Investigation of Regional Identity in Human Intestinal Stem Cells. Principal Investigator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases. Sep 2014-Aug 2019. U01DK103117.

Developmental Mechanisms of Trachea-Esophageal Birth Defects. Co-Investigator. National Institutes of Health. Jul 2017-Jun 2022. P01 HD093363-01.

Human Enteroids, Colonoids, and iPSC derived HIO's to study CFTR-related Disorders. Co-Investigator. National Institutes of Health. Sep 2018-Jun 2023. R01 DK112321-01A1.

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Michael A. Helmrath, MD

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