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Biographies

Find another Doctor or Researcher

High Res

Jeffery D. Molkentin, PhD

Professor | Howard Hughes Medical Institute Investigator

Professor, UC Department of Pediatrics

Phone: 513-636-3557

Fax: 513-636-5958

Email: jeff.molkentin@cchmc.org

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Specialties

Visit the Molkentin Lab.

Biography

Dr. Molkentin's research aims to understand the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation. His work has advanced the understanding of molecular events behind heart disease and muscular dystrophy.

In 2008 he was named a Howard Hughes Medical Institute (HHMI) investigator.

For a full description of Dr. Molkentin's work, please see his Faculty Lab Site in the Division of Molecular and Cardiovascular Biology.

Education and Training

BS Marquette University, Milwaukee WI, 1989.

PhD: Medical College of Wisconsin, 1994.

Publications

View PubMed Publications

Molkentin JD. The Transcription Factor C/EBP{beta} Serves as a Master Regulator of Physiologic Cardiac Hypertrophy.Circ Res. 2011 Feb 4;108(3):277-8.

Eder P, Molkentin JD. TRPC channels as effectors of cardiac hypertrophy.Circ Res. 2011 Jan 21;108(2):265-72.

Kehat I, Molkentin JD. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation. 2010 Dec 21;122(25):2727-35.

Sengupta A, Molkentin JD, Paik JH, Depinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.J Biol Chem. 2010 Dec 15.

Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Circ Res. 2011 Jan 21;108(2):176-83.

Liu Q, Molkentin JD. Protein kinase Cα as a heart failure therapeutic target. J Mol Cell Cardiol. 2010 Oct 16.

Wansapura JP, Millay DP, Dunn RS, Molkentin JD, Benson DW. Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice. Neuromuscul Disord. 2011 Jan;21(1):68-73.

Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.J Clin Invest. 2010 Oct 1;120(10):3680-7. doi: 10.1172/JCI43171.

van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD. The transcription factor GATA-6 regulates pathological cardiac hypertrophy.Circ Res. 2010 Oct 15;107(8):1032-40.

Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy.Nat Med. 2010 Aug;16(8):872-9.