Yan Xu, PhD
Title
Assisant Professor
Appointment
Assistant Professor of Pediatrics
Email
yan.xu@cchmc.org
Phone
513-636-8921
Fax
513-636-7868
Bio
Dr. Xu is an assistant professor in the Department of Pediatrics. Her primary appointment is in the Division of Pulmonary Biology, and her secondary appointment is in the Division of Biomedical Informatics. Her main research interests are functional genomics, bioinformatics and system biology. She is currently studying lung-specific gene expression profiling, transcription regulation and biological pathways. Her goals are to identify target genes or genetic modifiers that may play important roles in lung development and pathogenesis, and to identify and understand the regulatory elements that control the expression of those important lung genes. She also aims to integrate the data and information from new computational methods and experimental approaches in a synergistic way to gain a better understanding of molecular mechanisms underlying lung development and various lung diseases.
Credentials
BS: Pharmacology, Shanghai Medical University, China, 1986.
MS: Pathology, Shanghai Medical University, China, 1989.
PhD: Molecular and Cellular Pharmacology, University of South Alabama, Mobile, Alabama, 1997.
Awards and Honors
1993 Award for Scientific Progress of Shanghai city (Study on the relationship between the deficiency of glutathione peroxidase and Ke-Shan disease).
1998 Postdoctoral Fellowship from NIH.
1999 Postdoctoral Fellowship from NIH.
Research Grants and Contracts
2P01HL61646-06 (Weaver) 08/01/04-06/30/09
NIH/NHLBI
Regulation of Respiratory Epithelial Cell Homeostasis
- Project 4: Foxa1 and Foxa2 in Pulmonary Homeostasis. Whitsett JA (PI), Xu Y (Co-investigator). 10%
- Core B: Microarray/Bioinformatics Core. Xu Y (PI). 30%
R457-CR02 (Whitsett) 09/01/92-8/31/05 5%
Cystic Fibrosis Foundation (CFF) Development Grant, Component II, Bioinformatics Core. Xu Y (PI).
To develop gene therapy for cystic fibrosis
2HL050046-11 (Glasser) 04/01/04-03/31/08 5%
Role of SP-C in Familial Interstitial Lung Disease
Role: Co-investigator
5R01HL38859-17 (Whitsett) 04/01/03-3/31/08 30%
Perinatal Expression of Surfactant Protein Gene SP-B
Role: Co-investigator
R01HL63329-05 (Ikegami) 08/01/03-07/31/07 12%
Role of Surfactant Protein D in Surfactant Homeostasis
Role: Co-investigator
5R01 HL075770-02 (Whitsett) 09/30/03-08/31/07 8%
SHH and Alveolar Formation
Role: Co-investigator
Publications, Most Recent
Metzger DE, Xu Y, Shannon JM. Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev Dyn. 2007 May;236(5):1175-92.
Stahlman MT, Besnard V, Wert SE, Weaver TE, Dingle S, Xu Y, et al. Expression of ABCA3 in developing lung and other tissues. J Histochem Cytochem. 2007 Jan;55(1):71-83.
Dave V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, et al. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. The Journal of clinical investigation. 2006 Oct;116(10):2597-609.
Matsuzaki Y, Xu Y, Ikegami M, Besnard V, Park KS, Hull WM, et al. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol. 2006 Jul 1;177(1):527-37.
Xu Y, Liu C, Clark JC, Whitsett JA. Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(delta508) in the lung. J Biol Chem. 2006 Apr 21;281(16):11279-91.
Martis PC, Whitsett JA, Xu Y, Perl AK, Wan H, Ikegami M. C/EBPalpha is required for lung maturation at birth. Development (Cambridge, England). 2006 Mar;133(6):1155-64.
Bridges JP, Xu Y, Na CL, Wong HR, Weaver TE. Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. J Cell Biol. 2006 Jan 30;172(3):395-407.
Mucenski ML, Nation JM, Thitoff AR, Besnard V, Xu Y, Wert SE, et al. Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L971-9.
Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, et al. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 2005 Apr 8;280(14):13809-16.
Whitsett JA, Wert SE, Xu Y. Genetic disorders of surfactant homeostasis. Biol Neonate. 2005;87(4):283-7.
Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, et al. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14449-54.
Miller LA, Wert SE, Clark JC, Xu Y, Perl AK, Whitsett JA. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn. 2004 Sep;231(1):57-71.
Whitsett JA, Bachurski CJ, Barnes KC, Bunn PAJ, Case LM, Cook DN, et al. Functional genomics of lung disease. Second annual Pittsburgh International Lung Conference, October 2003. Am J Respir Cell Mol Biol. 2004 Aug;31(2 Suppl):S1-81.
Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, et al. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol. 2004 Apr;5(4):388-92.
Lian X, Yan C, Yang L, Xu Y, Du H. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L801-7.
DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, et al. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003 Sep 12;278(37):35574-83.
Xu Y, Clark JC, Aronow BJ, Dey CR, Liu C, Wooldridge JL, et al. Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency. J Biol Chem. 2003 Feb 28;278(9):7674-82.
Xu Y, Demarest K, Hitzemann R, Sikela JM. Gene coding variant in Cas1 between the C57BL/6J and DBA/2J inbred mouse strains: linkage to a QTL for ethanol-induced locomotor activation. Alcohol Clin Exp Res. 2002 Jan;26(1):1-7.
Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, et al. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63.
Xu Y, Ehringer M, Yang F, Sikela JM. Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. Alcohol Clin Exp Res. 2001 Jun;25(6):810-8.
Xu Y, Kakhniashvili DA, Gremse DA, Wood DO, Mayor JA, Walters DE, et al. The yeast mitochondrial citrate transport protein. Probing the roles of cysteines, Arg(181), and Arg(189) in transporter function. J Biol Chem. 2000 Mar 10;275(10):7117-24.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
