Minzhe Guo.

Assistant Professor, UC Department of Pediatrics

513-517-0076

Biography & Affiliation

Research Interests

Developing novel computational methods and software tools to support single cell multi-omics data analysis and integration for scientific discovery or to facilitate data management, access, and visualization; Applying expertise in computations, bioinformatics and single-cell multiomic data analysis to study important questions in lung development and diseases, including perinatal lung maturation and lung adaptation at birth, idiopathic pulmonary fibrosis, mucinous adenocarcinoma of the lung, lymphangioleiomyomatosis, bronchopulmonary dysplasia, cystic fibrosis, and alveolar capillary dysplasia

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Pulmonary Biology

Publications

Selected Publication

Generation of Pulmonary Endothelial Progenitor Cells for Cell-Based Therapy Using Interspecies Mouse-Rat Chimeras. Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2021.

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Muus, C; Luecken, MD; Eraslan, G; Sikkema, L; Waghray, A; Heimberg, G; Kobayashi, Y; Vaishnav, ED; Subramanian, A; Smillie, C; et al. Nature Medicine. 2021; 27:546-559.

In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; et al. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance. Du, Y; Ouyang, W; Kitzmiller, JA; Guo, M; Zhao, S; Whitsett, JA; Xu, Y. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:146-149.

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1373-1387.

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes. Wang, A; Chiou, J; Poirion, OB; Buchanan, J; Valdez, MJ; Verheyden, JM; Hou, X; Kudtarkar, P; Narendra, S; Newsome, JM; et al. eLife. 2020; 9.

CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions. Stuart, WD; Guo, M; Fink-Baldauf, IM; Coleman, AM; Clancy, JP; Mall, MA; Lim, F; Brewington, JJ; Maeda, Y. 2020; 2.

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Basil, MC; Katzen, J; Engler, AE; Guo, M; Herriges, MJ; Kathiriya, JJ; Windmueller, R; Ysasi, AB; Zacharias, WJ; Chapman, HA; et al. Cell Stem Cell. 2020; 26:482-502.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Nature Communications. 2019; 10.

Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.