• Research Objectives

    The Rothenberg laboratory has several broad objectives that encompass the specific research hypotheses currently being investigated in the laboratory.

    • Elucidating the cellular and molecular processes involved in allergic responses in the gastrointestinal tract and lung using approaches that include novel models of allergic responses in vivo and in vitro.
    • Testing the importance of key molecules including chemokines and cytokines in vivo using transgenic and gene-targeted mice.
    • Biochemically characterizing the transcriptional programs, regulating molecules and signal transduction mechanisms responsible for eosinophil development and activation.
    • Testing the importance and blockade of these pathways in patients with inflammatory diseases such as eosinophilic esophagitis (EE or EoE) and hypereosinophilic syndromes (HES).
    • Identifying genes and key check points that predispose to eosinophilic and other allergic disorders.
  • Ongoing Research Projects

    Gastrointestinal Eosinophils
    Gastrointestinal Eosinophils

    Gastrointestinal Eosinophils

    Regulation of Gastrointestinal Eosinophils. The major goals of this project are to analyze gastrointestinal eosinophils at baseline and during Th2-associated allergic responses in the gastrointestinal tract to determine mechanisms of their regulation during homeostasis and disease.

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    Steroids and Allergic Disease
    Steroids and Allergic Disease

    Steroids and Allergic Disease

    Mechanism of Steroid Action and Resistance in Allergic Disease. The major goal of this project is to optimize the efficacy of steroids for allergic disease by investigating the mechanisms of steroid action and resistance in allergic disease.  Model systems in vitro and in vivo are employed.

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    Allergic Disease Epigenetics
    Allergic Disease Epigenetics

    Allergic Disease Epigenetics

    Epigenetic Regulation of Allergic Disease. The major goals of this project are to elucidate gene-environment interactions in allergic disease and to define the epigenetic mechanisms that account for these interactions and their clinical and therapeutic significance.

    Related Publication
    Mechanistic Analysis of EoE
    Mechanistic Analysis of EoE

    Mechanistic Analysis of EoE

    Mechanistic Analysis of Eosinophilic Esophagitis. The major goal of this project is to understand the development of experimental eosinophilic esophagitis (EoE) in mice by exploring the mechanisms of antigen sensitization and dendritic cell involvement.

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    Epithelial Eotaxin-3 and EoE
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    Epithelial Eotaxin-3 and EoE

    Epithelial-derived Eotaxin-3 and Eosinophilic Esophagitis. The major goal of this project is to understand the role of epithelial-derived eotaxin-3 in human eosinophilic esophagitis (EoE). Studies involve cellular distribution of eotaxin-3 and its receptor, the role and mechanisms of an eotaxin-3 single-nucleotide polymorphism in disease pathogenesis and the effect of glucocorticoid therapy on eotaxin-3 expression and esophageal transcript profiles.

    Related Publication
    IL-13 and EoE
    IL-13 and EoE

    IL-13 and EoE

    IL-13 and Eosinophilic Esophagitis. The major goal of this project is to identify the expression and role of IL-13 in eliciting human eosinophilic esophagitis (EoE) and in experimental EoE in mice.

    Related Publication
    Genetics of EoE
    Genetics of EoE

    Genetics of EoE

    Candidate Gene Approach and Genome-wide Association Analysis for Eosinophilic Esophagitis. The major goal is to employ a candidate gene approach and genome-wide association studies (GWAS) to identify genetic risk factors for eosinophilic esophagitis (EoE) and to gain molecular insight into disease pathogenesis.

    Related Publication
    CBP in EoE
    CBP in EoE

    CBP in EoE

    Role of CREB-binding Protein (CBP) in Eosinophilic Esophagitis. The major goal of this project is to analyze the role of CREB-binding protein (CBP) in the pathogenesis of eosinophilic esophagitis (EoE).

    Related Publication
    Mechanistic Analysis of Asthma
    Mechanistic Analysis of Asthma

    Mechanistic Analysis of Asthma

    IL-13-associated Eosinophil Lung Responses. The major goal of this project is to broaden our understanding of asthma-associated lung pathology by aiming to clarify the unique and comparative effects of interrupting IL-4, IL-13 and/or their receptors in asthma.
    Related Publication
    Eotaxins / CCR3 in Asthma
    Eotaxins / CCR3 in Asthma

    Eotaxins / CCR3 in Asthma

    Role of Eotaxins and CCR3 in IL-13-induced Asthma. The major goal of this project is to define the individual and combined roles of eotaxin-1, eotaxin-2, IL-5 and CCR3 in IL-13-elicited lung responses.

    Related Publication
  • Desmoglein 1 in EE.

    Desmoglein 1 in EE - Read More. 

  • Diagnosing EE.

    EE Diagnosis is Invasive - Read More.

  • current-visual3-cdh26-jpg

    Cadherin-like 26 in EGID – Read More