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The Rothenberg laboratory has several broad objectives that encompass the specific research hypotheses currently being investigated in the laboratory.
Regulation of Gastrointestinal Eosinophils. The major goals of this project are to analyze gastrointestinal eosinophils at baseline and during Th2-associated allergic responses in the gastrointestinal tract to determine mechanisms of their regulation during homeostasis and disease.
Mechanism of Steroid Action and Resistance in Allergic Disease. The major goal of this project is to optimize the efficacy of steroids for allergic disease by investigating the mechanisms of steroid action and resistance in allergic disease. Model systems in vitro and in vivo are employed.
Epigenetic Regulation of Allergic Disease. The major goals of this project are to elucidate gene-environment interactions in allergic disease and to define the epigenetic mechanisms that account for these interactions and their clinical and therapeutic significance.
Mechanistic Analysis of Eosinophilic Esophagitis. The major goal of this project is to understand the development of experimental eosinophilic esophagitis (EoE) in mice by exploring the mechanisms of antigen sensitization and dendritic cell involvement.
Epithelial-derived Eotaxin-3 and Eosinophilic Esophagitis. The major goal of this project is to understand the role of epithelial-derived eotaxin-3 in human eosinophilic esophagitis (EoE). Studies involve cellular distribution of eotaxin-3 and its receptor, the role and mechanisms of an eotaxin-3 single-nucleotide polymorphism in disease pathogenesis and the effect of glucocorticoid therapy on eotaxin-3 expression and esophageal transcript profiles.
IL-13 and Eosinophilic Esophagitis. The major goal of this project is to identify the expression and role of IL-13 in eliciting human eosinophilic esophagitis (EoE) and in experimental EoE in mice.
Candidate Gene Approach and Genome-wide Association Analysis for Eosinophilic Esophagitis. The major goal is to employ a candidate gene approach and genome-wide association studies (GWAS) to identify genetic risk factors for eosinophilic esophagitis (EoE) and to gain molecular insight into disease pathogenesis.
Role of CREB-binding Protein (CBP) in Eosinophilic Esophagitis. The major goal of this project is to analyze the role of CREB-binding protein (CBP) in the pathogenesis of eosinophilic esophagitis (EoE).
Role of Eotaxins and CCR3 in IL-13-induced Asthma. The major goal of this project is to define the individual and combined roles of eotaxin-1, eotaxin-2, IL-5 and CCR3 in IL-13-elicited lung responses.
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