University of Cincinnati Researchers
University of Cincinnati College of Engineering and Applied Science, Department of Biomedical Engineering
The Barrile Lab focus is on combining patient-derived stem cells and reverse engineering approaches to establish an highly translational platform designed to capture the complex and dynamic nature of brain-ischemic stroke and metastatic lung-cancer. The lab aims to explore the cellular and molecular mechanisms that govern organ-functions during the homeostasis and disease state, and how these processes can be therapeutically targeted in order to create personalized therapies.
University of Cincinnati College of Engineering and Applied Science, Electrical Engineering and Biomedical Engineering
The Esfandiari Lab uses integrated bioengineering and stem cell technologies to design and fabricate nano-scale biosensors and actuators to monitor the biophysical and biochemical microenvironment of living organoids. These tools accelerate the next generation of organoid based-therapeutic screens and enable personalize medicine.
Department of Pharmacology and System Physiology, University of Cincinnati
The Hong Lab investigates molecular mechanisms of circadian rhythms and their functions in other cellular processes such as cell cycle and metabolism. Currently, we focus on identifying molecular components that connect the circadian clock and cell cycle, and the consequences of this coupling in intestinal stem cell regeneration and proliferation using mouse and human organoids.
Adjunct Research Professor, Department of Surgery, University of Cincinnati College of Medicine
The Supp Lab focuses on wound healing and tissue engineering. We are studying the molecular mechanisms of keloid and hypertrophic scar formation so that improved approaches for suppressing scar and promoting regenerative healing can be developed. Additionally, we are developing tissue-engineered substitutes for skin, oral mucosa, and esophagus for treatment of traumatic wounds, such as burns, and the hereditary disease Recessive Dystrophic Epidermolysis Bullosa. These engineered tissues may be used for ex vivo gene therapy following genome editing of patient-derived epithelial stem cells, mesenchymal cells, and/or iPS cells.
Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati
The Weiss Lab is focused on understanding human intestinal pathogens, including E. coli O157:H7, the "hamburger E. coli". Currently there is no treatment for this potentially fatal pediatric disease. Mice are not susceptible to O157:H7, and the use of stem-cell derived human intestinal organoids affords an unprecedented approach to study potential therapeutic interventions.
