Cancer and Blood Diseases Institute

  • Research Faculty

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    Oncology Faculty

    A photo of Michael Absalon.

    Michael J. Absalon, MD, PhD

    focuses on developing new therapies and combinations of therapies for pediatric leukemias and lymphomas. He is currently investigating the therapeutic potential of combining the new targeted drug sorafenib with conventional chemotherapy for relapsed AML.

    513-636-4266
    michael.absalon@cchmc.org

    Michael J. Absalon, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: michael.absalon@cchmc.org

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    Specialties

    Relapsed leukemia; lymphoma; new therapeutics; ataxia telangiectasia; DNA damage response mechanisms

    Education and Training

    BS: Lewis and Clark College, Portland, OR, 1987.

    PhD: Massachusetts Institute of Technology, Cambridge, MA, 1994.

    MD: Oregon Health Sciences University, Portland, OR, 1998.

    Fellowship: St. Jude Children's Research Hospital, Memphis, TN, 2005.

    Publications

    View PubMed Publications
    A photo of Denise Adams.

    Denise M. Adams, MD Marjory J. Johnson Chair of Vascular Tumor Translational Research

    is a nationally recognized expert on vascular anomalies with a keen interest in rare vascular tumors and life threatening malformations. She leads a clinical and translational research program to develop new therapies for these conditions and currently is the PI of a clinical study of sirolimus, a mTOR inhibitor, in the treatment of complicated vascular anomalies, the first trial of a new therapy for these conditions.

    513-636-4266
    denise.adams@cchmc.org

    Denise M. Adams, MD

    Marjory J. Johnson Chair of Vascular Tumor Translational Research

    Medical Director, Comprehensive Hemangioma and Vascular Malformation Center

    Fellowship Director, Hematology / Oncology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: denise.adams@cchmc.org

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    Biography

    Dr. Denise Adams is the medical director of the Hemangioma and Vascular Malformations Center. She is one of the medical physicians who evaluate patients to identify the proper diagnosis and develop with families an optimal treatment plan. She is trained in hematology/oncology. Dr. Adams obtained her schooling from Georgetown University. She first came to Cincinnati Children’s in 2003, and has strived since that time to provide exemplary care for the children served here within our multidisciplinary team. One of the vascular team’s main priorities has been establishing standards of care for patients with these diagnoses so they can follow outcome measures. Of key interest to Dr. Adams, is the improving of the care of patients with kaposiform hemangioendotheliomas (KHE) and other rare vascular tumors. Dr. Adams was awarded the Marjory J. Johnson Chair of Vascular Tumor Translational Research for her impact and leadership in the advancement of knowledge of vascular anomalies and the transformation of care for her patients. Dr. Adams has led one of the first prospective NIH-funded trials for the treatment of complicated vascular anomalies; further studies are in development. Clinical trial summaries can be seen on www.ClinicalTrial.gov.

    Education and Training

    MD: Georgetown University School of Medicine, 1988.

    Post-Graduate: Georgetown University, 1983.

    BSN: Georgetown University, 1982.

    Publications

    View PubMed Publications
    A photo of Karen Burns.

    Karen C. Burns, MD, MS Director, Cancer Survivorship Center

    conducts research on cancer survivorship and serious late effects of cancer treatment, including obesity, heart problems, fertility issues, increased risk of second cancers, and long-term outcomes of cancer survivors. She is also leading development of a fertility preservation program for children and adolescents undergoing chemotherapy as well as other unique medical and support services for adolescent and young adult cancer patients.

    513-636-4266
    karen.burns@cchmc.org

    Karen C. Burns, MD, MS

    Director, Cancer Survivorship Center

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: karen.burns@cchmc.org

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    Education and Training

    BA: University of Pennsylvania, Philadelphia, PA, 1995.

    MD: Temple University, Philadelphia, PA, 1999.

    Residency: Pediatrics, St. Christopher's Hospital for Children in Philadelphia, PA, 2002.

    MS: Medical College of Wisconsin, 2005.

    Fellowship: Medical College of Wisconsin, 2005.

    Publications

    View PubMed Publications
    A photo of Lionel Chow.

    Lionel M. L. Chow, MD, PhD

    studies high-grade gliomas, which are aggressive brain tumors in adults and children with limited treatment options. Using a combination of novel and robust laboratory models coupled with the study of human tumor material, the lab’s goals are to better understand the cellular origins and molecular underpinnings of these diseases in order to design and test novel therapies that will hopefully improve patient outcome.
    Visit the Chow Lab

    513-803-1369
    lionel.chow@cchmc.org

    Lionel M. L. Chow, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1369

    Fax: 513-803-1083

    Email: lionel.chow@cchmc.org

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    Specialties

    Clinical Interests

    Pediatric neuro-oncology

    Research Interests

    Mouse models for glioma; molecular profiling of tumor mutations; biomarkers of tumor progression; novel therapeutic agents for glioma

    Visit the Chow Lab

    Biography

    Lionel Chow, MD, PhD, received his medical and graduate degrees from McGill University in Montreal, Canada, where his research focused on the regulation of T-lymphocyte signaling by the intracellular tyrosine protein kinases Lck and Csk.

    Following his clinical training in pediatrics and pediatric hematology / oncology at the Hospital for Sick Children in Toronto, Canada, he moved to St. Jude Children’s Research Hospital in Memphis, Tenn., to pursue his research interests.

    Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease. Using these models and interfacing with clinical trials in the Neuro-Oncology Program as well as those from national consortia such as the Children's Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC), Chow’s laboratory will continue research in this area with the goals of better understanding the origins of this form of cancer and improving patient outcomes.

    Education and Training

    PhD: McGill University, Montreal, Quebec, Canada, 1996.

    MDCM: McGill University, Montreal, Quebec, Canada, 1997.

    Residency: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 1997-2000.

    Clinical Fellowship: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 2000-2003.

    Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2003-2009.

    Clinical Fellowship: St. Jude Children’s Research Hospital, Memphis TN, 2008-2009.

    Certification: Pediatrics, 2000.

    Publications

    View PubMed Publications

    Grants

    2013 – 2014 Sophie’s Angel Run Foundation
    “Preclinical Testing of Notch and mTor Inhibition in a Mouse Model for High-Grade Glioma” 

    2011 – 2014 St. Baldrick’s Foundation Scholars Award
    "Molecular targeting of pediatric high-grade glioma"

    2011 – 2015 Sontag Foundation Distinguished Scientist Award
    "Molecular targeting of high-grade astrocytoma"

    A photo of Dr. Biplab Dasgupta.

    Biplab Dasgupta, PhD, MS

    focuses on the integration of metabolic and signaling pathways in neural cells including neural and brain cancer stem cells. He is particularly interested in understanding the link between cellular energy sensing pathways with cellular signaling circuits that are controlled by growth factors and their receptors. Mouse models are used to understand the development of high grade human and mouse brain tumor (glioma).
    Visit the Dasgupta Lab.

    513-803-1370
    biplab.dasgupta@cchmc.org

    Biplab Dasgupta, PhD, MS

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1370

    Fax: 513-803-1083

    Email: biplab.dasgupta@cchmc.org

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    Specialties

    Biography

    Biplab Dasgupta, PhD, MS, completed his doctorate in molecular biology and immunology at the Indian Institute of Chemical Biology, Calcutta, and a postdoctoral fellowship at Washington University School of Medicine, Saint Louis. Dr. Dasgupta came to Cincinnati Children's Hospital Medical Center in August 2009 as an assistant professor of pediatrics. He is interested in understanding how neural cell / stem cell metabolic and energy status is linked to cell cycle, lineage commitment, differentiation and tumorigenesis. His other interests include genetic, developmental, post-translational, tissue- and stimuli–specific regulation of the subunits that constitute the AMP kinase complex.

    Education and Training

    PhD: Indian Institute of Chemical Biology, Calcutta, 2003

    Postdoctoral Fellowship:
    Washington University School of Medicine, Saint Louis

    Publications

    View PubMed Publications

    Grants

    Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase. Principal Investigator. National Institute of Neurological Disorders and Stroke (NINDS). July 2012 – June 2017.
    A photo of Mariko DeWire.

    Mariko D. DeWire, MD

    focuses on developing novel therapeutics to treat children with all central nervous system tumors including young children (less than 4 years of age), very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas. Additionally, she has an interest in maximizing the quality of life in children and young adults diagnosed with brain tumors.

    513-636-4266
    mariko.dewire@cchmc.org

    Mariko D. DeWire, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Email: mariko.dewire@cchmc.org

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    Biography

    Mariko D. DeWire, MD, completed her graduate medical training at the Boonshoft School of Medicine at Wright State University, residency training in pediatrics at Lebonheur Children's Medical Center, and pediatric hematology/oncology training at St. Jude Children's Research Hospital in Memphis, Tennessee, with a focus on pediatric neuro-oncology.

    Dr. DeWire's clinical and academic interests pertain to children and families affected by central nervous system tumors. She is a member of the Central Nervous System (Brain Tumor) Committee in the Children's Oncology Group (COG) as well as the Cincinnati Children's co-principal investigator for the Pediatric Brain Tumor Consortium (PBTC).

    Education and Training

    MD: Boonshoft School of Medicine at Wright State University, Dayton, OH.

    Residency: Pediatrics, University of Tennessee College of Medicine.

    Fellowship: Pediatric Hematology/Oncology, University of Tennessee College of Medicine and St. Jude Children’s Research Hospital.

    Publications

    View PubMed Publications
    A photo of Rachid Drissi.

    Rachid Drissi, PhD

    studies replicative senescence or cellular aging, believed to be a tumor suppressor mechanism by which normal cells limit cell proliferation to prevent genome instability and cancer. The long-term goal of our research program is to examine telomere disruption signaling to DNA damage pathway and senescence. We are also developing a combination therapy that includes telomere disruption to improve the outcome for children with brain tumors. 

    513-636-4266
    rachid.drissi@cchmc.org

    Rachid Drissi, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: rachid.drissi@cchmc.org

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    Education and Training

    BS: University of Rouen, France, 1983.

    MS: University of Rouen, France, 1984.

    MS: University of Paris VI, France, 1988.

    PhD: University of Paris VI, France, 1994.

    Publications

    View PubMed Publications
    A photo of Maryam Fouladi.

    Maryam Fouladi, MD, MSc, FRCPC Medical Director, Neuro-Oncology Program

    serves as chair for the CNS Tumor New Agents/Relapse Committee for the Children’s Oncology Group, and as member of the steering committee for the COG CNS Tumor Committee and the Collaborative Ependymoma Research Network (CERN). She serves as local and national study chair for active open clinical trials that test new approaches to treat children with very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas.

    513-636-4266
    maryam.fouladi@cchmc.org

    Maryam Fouladi, MD, MSc, FRCPC

    Medical Director, Neuro-Oncology Program

    Cincinnati Children's Principal Investigator, Collaborative Ependymoma Research Network

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: maryam.fouladi@cchmc.org

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    Biography

    Maryam Fouladi, MD, MSc, graduated from the University of Toronto School of Medicine, and completed her pediatric residency and hematology / oncology fellowship training at the Hospital for Sick Children in Toronto, Canada. Dr. Fouladi then completed her neuro-oncology fellowship training at St. Jude Children's Research Hospital, and later completed further training in the molecular pharmacology department at St. Jude before becoming a  neuro-oncology faculty member in 2000. She served as the chair of the Phase I Committee at St. Jude.

    Dr. Fouladi moved to Cincinnati Children's in 2008 to direct the neuro-oncology program. She is currently chair for the CNS Tumor New Agent Committee for the Children’s Oncology Group. She is a member of the steering committee for the COG CNS Tumor Committee as well as the Developmental Therapeutics group at COG, and is a member of the Collaborative Ependymoma Research Network (CERN). She serves as local and national study chair (through CERN, COG and the Pediatric Brain Tumor Consortium) for clinical trials that test new approaches to treat children with very poor prognosis tumors such as high-grade gliomas and diffuse intrinsic pontine gliomas.

    Education and Training

    BS: Human Biology, University of Toronto, Toronto, Canada, 1987. 

    MD: University of Toronto, Toronto, Canada, 1991.

    MSc: Institute of Medical Science, University of Toronto, Toronto, Canada, 2002.

    Publications

    View PubMed Publications
    A photo of James Geller.

    James I. Geller, MD Medical Director, Kidney and Liver Tumors Program

    focuses on children and young adults affected by solid tumors. Dr. Geller's expertise is recognized internationally, as witnessed by his appointments to the Children's Oncology Group (COG) Renal Tumor, Liver Tumor, Retinoblastoma and Central Nervous System (Brain Tumor) Committees. Dr. Geller directs and spearheads local and national studies in these areas, with an emphasis on novel therapeutics.

    513-636-4266
    james.geller@cchmc.org

    James I. Geller, MD

    Medical Director, Kidney and Liver Tumors Program

    Co-Medical Director, Retinoblastoma Program

    Associate Director, Global Cancer Programs

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: james.geller@cchmc.org

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    Specialties

    Clinical Interests

    Developmental therapeutics; renal / liver / retinoblastoma / neuro-oncology

    Research Interests

    Elucidating ways to translate the use of biological response modifiers in combination with conventional chemotherapeutics

    Biography

    James I. Geller, MD, completed his undergraduate training at Dartmouth College, graduate medical training at the Sackler School of Medicine, residency training in pediatrics at New York Medical College and pediatric hematology / oncology training at St. Jude Children's Research Hospital. His current appointment is with the University of Cincinnati and Children's Hospital Medical Center in the capacity of associate professor of pediatrics.

    Dr. Geller's clinical and academic interests pertain to children and families affected by solid tumors, including brain tumors. Dr. Geller's expertise is recognized both nationally and internationally in the fields of retinoblastoma, renal tumors, liver tumors and brain tumors, as witnessed by his appointments to the Children's Oncology Group (COG) Rare/Retinoblastoma Committee as both a Steering/Voting Member and as liaison to the COG Young Investigator Committee; the COG Renal Tumor Committee (RTC) as Steering/Voting Member, RTC Sub-Committee Chair of Developmental Therapeutics, and RTC liaison to both the COG Developmental Therapeutics Committee and the Pediatric Preclinical Testing Program Guidance Committee; and to the Central Nervous System (Brain Tumor) Committee as a voting member. Dr. Geller has been an invited speaker at numerous national and international meetings and symposia and spearheads both local and national clinical research initiatives in these areas, with an emphasis on finding new treatment options.

    Education and Training

    MD: Sackler School of Medicine, 1997.

    Residency: New York Medical College, 2000.

    Fellowship: St Jude Children's Research Hospital, 2004.

    Certification: Pediatrics, 2000, 2007; Pediatric Hematology / Oncology, 2005.

    Publications

    View PubMed Publications
    A photo of Adrienne M. Hammill.