Cancer and Blood Diseases Institute

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    Oncology Faculty

    A photo of Michael Absalon.

    Michael J. Absalon, MD, PhD

    focuses on developing new therapies and combinations of therapies for pediatric leukemias and lymphomas. He is currently investigating the therapeutic potential of combining the new targeted drug sorafenib with conventional chemotherapy for relapsed AML.

    513-636-4266
    michael.absalon@cchmc.org

    Michael J. Absalon, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: michael.absalon@cchmc.org

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    Specialties

    Relapsed leukemia; lymphoma; new therapeutics; ataxia telangiectasia; DNA damage response mechanisms

    Education and Training

    BS: Lewis and Clark College, Portland, OR, 1987.

    PhD: Massachusetts Institute of Technology, Cambridge, MA, 1994.

    MD: Oregon Health Sciences University, Portland, OR, 1998.

    Fellowship: St. Jude Children's Research Hospital, Memphis, TN, 2005.

    Publications

    View PubMed Publications
    A photo of Denise Adams.

    Denise M. Adams, MD Marjory J. Johnson Chair of Vascular Tumor Translational Research

    is a nationally recognized expert on vascular anomalies with a keen interest in rare vascular tumors and life threatening malformations. She leads a clinical and translational research program to develop new therapies for these conditions and currently is the PI of a clinical study of sirolimus, a mTOR inhibitor, in the treatment of complicated vascular anomalies, the first trial of a new therapy for these conditions.

    513-636-4266
    denise.adams@cchmc.org

    Denise M. Adams, MD

    Marjory J. Johnson Chair of Vascular Tumor Translational Research

    Medical Director, Comprehensive Hemangioma and Vascular Malformation Center

    Fellowship Director, Hematology / Oncology

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: denise.adams@cchmc.org

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    Biography

    Denise Adams, MD, is fellowship director of the Hematology / Oncology Fellowship Program and medical director of the Hemangioma and Vascular Malformations Center at Cincinnati Children’s. One of the vascular team’s main priorities has been establishing standards of care for patients with these diagnoses so they can follow outcome measures. Of key interest to Dr. Adams, as an oncologist, is the improvement in care of patients with kaposiform hemangioendotheliomas (KHE). The team of experts has established a clinical registry for these patients to gain insight into the clinical characteristics of KHE patients and the long term outcomes of these patients. They also have a phase II FDA funded trial for complicated vascular anomalies and KHE patients are included in this trial. These tumors are rare but have a very high mortality and morbidity rate. It is important that the group learn more about the clinical characteristics, phenotype, biomarkers which can lead to further investigations and clinical trials.

    Education and Training

    MD: Georgetown University School of Medicine, 1988.

    Post-Graduate: Georgetown University, 1983.

    BSN: Georgetown University, 1982.

    Publications

    View PubMed Publications

    Grants

    Phase II Study of Rapamycin for Complicated Vascular Anomalies. Food and Drug Administration. Sep 2009 - Aug 2013. #R01 FD 003712.

    A photo of Karen Burns.

    Karen C. Burns, MD, MS Director, Cancer Survivorship Center

    conducts research on cancer survivorship and serious late effects of cancer treatment, including obesity, heart problems, fertility issues, increased risk of second cancers, and long-term outcomes of cancer survivors. She is also leading development of a fertility preservation program for children and adolescents undergoing chemotherapy as well as other unique medical and support services for adolescent and young adult cancer patients.

    513-636-4266
    karen.burns@cchmc.org

    Karen C. Burns, MD, MS

    Director, Cancer Survivorship Center

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4266

    Fax: 513-636-3549

    Email: karen.burns@cchmc.org

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    Education and Training

    BA: University of Pennsylvania, Philadelphia, PA, 1995.

    MD: Temple University, Philadelphia, PA, 1999.

    Residency: Pediatrics, St. Christopher's Hospital for Children in Philadelphia, PA, 2002.

    MS: Medical College of Wisconsin, 2005.

    Fellowship: Medical College of Wisconsin, 2005.

    Publications

    View PubMed Publications
    A photo of Lionel Chow.

    Lionel M.L. Chow, MD, PhD

    studies high-grade gliomas, which are aggressive brain tumors in adults and children with limited treatment options. Using a combination of novel and robust laboratory models coupled with the study of human tumor material, the lab’s goals are to better understand the cellular origins and molecular underpinnings of these diseases in order to design and test novel therapies that will hopefully improve patient outcome.
    Visit the Chow Lab

    513-803-1369
    lionel.chow@cchmc.org

    Lionel M.L. Chow, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1369

    Fax: 513-803-1083

    Email: lionel.chow@cchmc.org

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    Specialties

    Clinical Interests

    Pediatric neuro-oncology

    Research Interests

    Mouse models for glioma; molecular profiling of tumor mutations; biomarkers of tumor progression; novel therapeutic agents for glioma

    Visit the Chow Lab

    Biography

    Lionel Chow, MD, PhD, received his medical and graduate degrees from McGill University in Montreal, Canada, where his research focused on the regulation of T-lymphocyte signaling by the intracellular tyrosine protein kinases Lck and Csk.

    Following his clinical training in pediatrics and pediatric hematology / oncology at the Hospital for Sick Children in Toronto, Canada, he moved to St. Jude Children’s Research Hospital in Memphis, Tenn., to pursue his research interests.

    Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease. Using these models and interfacing with clinical trials in the Neuro-Oncology Program as well as those from national consortia such as the Children's Oncology Group (COG) and the Pediatric Brain Tumor Consortium (PBTC), Chow’s laboratory will continue research in this area with the goals of better understanding the origins of this form of cancer and improving patient outcomes.

    Education and Training

    PhD: McGill University, Montreal, Quebec, Canada, 1996.

    MDCM: McGill University, Montreal, Quebec, Canada, 1997.

    Residency: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 1997-2000.

    Clinical Fellowship: The Hospital for Sick Children, University of Toronto, Toronto, Canada, 2000-2003.

    Postdoctoral Fellowship: St. Jude Children’s Research Hospital, Memphis, TN, 2003-2009.

    Clinical Fellowship: St. Jude Children’s Research Hospital, Memphis TN, 2008-2009.

    Certification: Pediatrics, 2000.

    Publications

    View PubMed Publications

    Grants

    2013 – 2014 Sophie’s Angel Run Foundation
    “Preclinical Testing of Notch and mTor Inhibition in a Mouse Model for High-Grade Glioma” 

    2011 – 2014 St. Baldrick’s Foundation Scholars Award
    "Molecular targeting of pediatric high-grade glioma"

    2011 – 2013 Bear Necessities Pediatric Cancer Foundation
    "Micro-RNA expression in pediatric high-grade glioma"

    2011 – 2013 The Childhood Brain Tumor Foundation
    "Micro-RNA expression in pediatric high-grade glioma"

    2011 – 2015 Sontag Foundation Distinguished Scientist Award
    "Molecular targeting of high-grade astrocytoma"

    A photo of Dr. Biplab Dasgupta.

    Biplab Dasgupta, PhD, MS

    focuses on the integration of metabolic and signaling pathways in neural cells including neural and brain cancer stem cells. He is particularly interested in understanding the link between cellular energy sensing pathways with cellular signaling circuits that are controlled by growth factors and their receptors. Mouse models are used to understand the development of high grade human and mouse brain tumor (glioma).
    Visit the Dasgupta Lab.

    513-803-1370
    biplab.dasgupta@cchmc.org

    Biplab Dasgupta, PhD, MS

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-1370

    Fax: 513-803-1083

    Email: biplab.dasgupta@cchmc.org