Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration. Scientific Reports. 2022; 12:1655.
.Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis. Development (Cambridge). 2022; 149:dev200446.
.TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. Journal of Allergy and Clinical Immunology. 2022; 149:79-88.
.Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis. Nature Communications. 2021; 12:6332.
.Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. Editor, Aster JC. PLoS Genetics. 2021; 17:e1009039.
.Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney. Journal of the American Society of Nephrology : JASN. 2021; 32:1898-1912.
.Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets. Editor, Greally JM. PLoS Genetics. 2021; 17:e1009574.
.The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis. Journal of the American Society of Nephrology : JASN. 2021; 32:1097-1112.
.Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Editor, Koo B-K. PLoS biology. 2020; 18:e3000850.
.Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020; 34:9512-9530.
.Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9:e53659.
.Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. 2020; 52:731-747.e8.
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Raphael Kopan, PhD
William K. Schubert Professor of Pediatrics, University of Cincinnati College of Medicine
Director of the Division of Developmental Biology, Cincinnati Children's Hospital Medical Center
Mailing Address:
3333 Burnet Avenue, MLC 7029
Cincinnati, OH 45229-3039
Phone: 513-636-2090
Fax: 513-636-4317
Email: raphael.kopan@cchmc.org