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The goal of our research program is to investigate cellular and molecular mechanisms controlling normal hematopoietic cell functions. We are particularly interested in understanding basic intracellular signaling transduction mechanisms in hematopoietic cell functions with the ultimate goal of developing new treatment options for hematological and immunological disorders. The lab has focused on investigating how signaling molecules govern hematopoietic stem cell self-renewal and engraftment, and neutrophil migration and trafficking. The lab has had a longstanding interest in Rho GTPase signaling. Rho GTPases are major regulator of cell cytoskeleton rearrangement and transcriptional responses and play major roles in cell shape changes, cell migration, and cell fates.
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