Marie-Dominique Filippi, PhD

A photo of Marie-Dominique Filippi.

Member, Division of Experimental Hematology & Cancer Biology

Director, Comprehensive Mouse and Cancer Core

Associate Professor, UC Department of Pediatrics

513-636-0991

513-636-3768

Biography & Affiliation

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

PharmD: University of Rene Descartes, Paris, France, 1998.

Residency: Hematopathology, University of Rene Descartes, Assistance public Hospital of Paris, Paris, France.

Certification: Hematopathology, 2001.

PhD: University of Denis Diderot, Paris, France, 2001.

Publications

Selected Publication

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Neutrophil transendothelial migration: updates and new perspectives. Filippi, M. Blood. 2019; 133:2149-2158.

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Filippi, M; Ghaffari, S. Blood. 2019; 133:1943-1952.

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M. Nature Communications. 2017; 8.

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M. Journal of Experimental Medicine. 2014; 211:1741-1758.

p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M. Leukemia. 2013; 27:2209-2219.

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M. Blood. 2012; 120:3563-3574.

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M. Blood. 2009; 114:3557-3566.

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Szczur, K; Zheng, Y; Filippi, M. Blood. 2009; 114:4527-4537.

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M. Blood. 2006; 108:4205-4213.