A photo of Marie-Dominique Filippi.

Marie-Dominique Filippi, PhD

  • Member, Division of Experimental Hematology & Cancer Biology
  • Director, Comprehensive Mouse and Cancer Core
  • Professor, UC Department of Pediatrics

About

PharmD: University of Rene Descartes, Paris, France, 1998.

Residency: Hematopathology, University of Rene Descartes, Assistance Public Hospital of Paris, Paris, France.

Certification: Hematopathology, 2001.

PhD: University of Denis Diderot, Paris, France, 2001.

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Selected

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Selected

Neutrophil transendothelial migration: updates and new perspectives. Filippi, M. Blood. 2019; 133:2149-2158.

Selected

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Filippi, M; Ghaffari, S. Blood. 2019; 133:1943-1952.

Selected

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M. Nature Communications. 2017; 8.

Selected

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M. Journal of Experimental Medicine. 2014; 211:1741-1758.

Selected

p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M. Leukemia. 2013; 27:2209-2219.

Selected

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M. Blood. 2012; 120:3563-3574.

Selected

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Szczur, K; Zheng, Y; Filippi, M. Blood. 2009; 114:4527-4537.

Selected

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M. Blood. 2009; 114:3557-3566.

Selected

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M. Blood. 2006; 108:4205-4213.