Marie-Dominique Filippi, PhD

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; Mulloy, J; Kofron, M; Salomonis, N; Grimes, HL; Filippi, M-D. Cell Stem Cell. 2020; 26(3):420-430.e6.

Neutrophil transendothelial migration: updates and new perspectives. Filippi, M-D. Blood. 2019; 133(20):2149-2158.

Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities. Filippi, M-D; Ghaffari, S. Blood. 2019; 133(18):1943-1952.

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M-D. Nature Communications. 2017; 8:14382.

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M-D. Journal of Experimental Medicine (JEM). 2014; 211(9):1741-1758.

p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M-D. Leukemia. 2013; 27(11):2209-2219.

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M-D. Blood. 2012; 120(17):3563-3574.

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Szczur, K; Zheng, Y; Filippi, M-D. Blood. 2009; 114(20):4527-4537.

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M-D. Blood. 2009; 114(17):3557-3566.

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M-D. Blood. 2006; 108(13):4205-4213.