Marie-Dominique Filippi, PhD

About

PharmD: University of Rene Descartes, Paris, France, 1998.

Residency: Hematopathology, University of Rene Descartes, Assistance Public Hospital of Paris, Paris, France.

Certification: Hematopathology, 2001.

PhD: University of Denis Diderot, Paris, France, 2001.

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Selected

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; Mulloy, J; Kofron, M; Salomonis, N; Grimes, HL; Filippi, M. Cell Stem Cell. 2020; 26:420-430.e6.

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p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M. Nature Communications. 2017; 8:14382.

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The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M. The Journal of Experimental Medicine. 2014; 211:1741-1758.

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p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M. Leukemia. 2013; 27:2209-2219.

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Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M. Blood. 2012; 120:3563-3574.

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Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M. Blood. 2009; 114:3557-3566.

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