A photo of Marie-Dominique Filippi.

Marie-Dominique Filippi, PhD


  • Member, Division of Experimental Hematology & Cancer Biology
  • Director, Comprehensive Mouse and Cancer Core
  • Professor, UC Department of Pediatrics

About

Publications

Selected

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Selected
Selected

p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge, A; Xu, J; Javier, J; Mose, E; Kumar, S; Kapur, R; Srour, EF; Malik, P; Aronow, BJ; Filippi, M. Nature Communications. 2017; 8.

Selected

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation. Kumar, S; Xu, J; Kumar, RS; Lakshmikanthan, S; Kapur, R; Kofron, M; Chrzanowska-Wodnicka, M; Filippi, M. Journal of Experimental Medicine. 2014; 211:1741-1758.

Selected

p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman, R; Kumar, RS; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, JA; Filippi, M. Leukemia. 2013; 27:2209-2219.

Selected

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Kumar, S; Xu, J; Perkins, C; Guo, F; Snapper, S; Finkelman, FD; Zheng, Y; Filippi, M. Blood. 2012; 120:3563-3574.

Selected

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling. Szczur, K; Zheng, Y; Filippi, M. Blood. 2009; 114:4527-4537.

Selected

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu, H; Eleswarapu, S; Geiger, H; Szczur, K; Daria, D; Zheng, Y; Settleman, J; Srour, EF; Williams, DA; Filippi, M. Blood. 2009; 114:3557-3566.

Selected

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Szczur, K; Xu, H; Atkinson, S; Zheng, Y; Filippi, M. Blood. 2006; 108:4205-4213.