Ratner Lab

  • Alterations in NF1 Mutant Schwann Cells

    The lab is currently leading an international effort to define the differences between normal Schwann cells and NF1 mutant Schwann cells that may be relevant to neurofibroma formation and to the development of malignant peripheral nerve sheath tumor (MPNST).  Our current approach is to use large-scale microarray analysis to identify misregulated genes, and then to test their effect on tumorigenesis in transgenic mice. 

    The microarray analysis is being conducted in collaboration with Shyra Miller, PhD, and Bruce Aronow, PhD. This approach has already led to the identification of BLBP (brain lipid binding protein) as a potential novel target.  Another project developing from these studies is characterizing the role of epidermal growth factor receptor (EGFR) in neurofibroma formation, with the goal of using it as a therapeutic target in clinical trials. 

  • Related Publications

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    2010

    Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of eyes absent homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. Jan 21;29(3):368-79. Jan, 2010.

    2009

    Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S, Jegga AG, Li H, Upadhyaya M, Giovannini M, Muir D, Wallace MR, Lopez E, Serra E, Nielsen GP, Lazaro C, Stemmer-Rachamimov A, Page G, Aronow BJ, Ratner N. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Mol Med. 1(4):236-48. Jul, 2009.

    Other Significant Publications

    Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, Kaiser S, Aronow BJ, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle DE, Watson MA, Perry A, Gutmann DH, Ratner N. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res. 66(5):2584-91. Mar, 2006.

 
  • Alterations in NF1 Mutant Schwann Cells.

    click to enlarge

    Alterations in NF1 Mutant Schwann Cells.

    This chart depicts microarray data examining gene expression patterns in normal, tumor and MPNST human Schwann cells.

  • Contact Us

    For more information about the lab, contact Nancy Ratner, PhD, at 513-636-9469.