• Meet the Ratner Lab

  • Bresnen-Bethany-Ratner Lab_200
    Bresnen-Bethany-Ratner Lab_60

    Bethany Bresnen

    My responsibility is to support Dr. Ratner and her lab, taking care of the behind the scenes administrative details so they can do what they do and each work in his/her genius.  I also every once in a while get to dabble in Photoshop and editorial work…  It’s a privilege and inspiration to work with such kind, intelligent, passionate people every day.  Dr. Ratner sets high personal and professional standards by example.

    Bethany Bresnen

    Meghan Brundage headshot.
    Meghan Brundage headshot.

    Meghan Brundage

    Project examines the regulatory pathways downstream of Ras involved in tumorigenesis leading to neurofibromatosis type 1 (NF1). In particular, she is focused on those pathways involving SOX9, a biomarker of neurofibromas and malignant peripheral nerve sheath tumors. 

    Meghan Brundage

    Choi-Kwangmin-Ratner Lab_200
    Choi-Kwangmin-Ratner Lab_60

    Kwangmin Choi

    Kwangmin Choi

    Li Guo headshot.
    Li Guo headshot.

    Li Guo, PhD

    Research fellow studying the role of Rho GTPases Rac1 and Cdc42 in Schwann cell growth and tumorigenesis. 

    Li Guo

    Hennigan-Robert-Ratner Lab_200(2)
    Hennigan-Robert-Ratner Lab_60(2)

    Robert Hennigan

    Robert Hennigan

    Edwin Jousma headshot.
    Edwin Jousma headshot.

    Edwin Jousma, MS

    Visiting research scientist working in the framework of the NF1 preclinical therapeutic trial. Screening candidate drugs that may prevent neurofibromas from growing.

    Edwin Jousma

    Debra Mayes headshot.
    Debra Mayes headshot.

    Debra Mayes, PhD

    Research fellow focusing on the role and mechanism of the Nf1 protein in regulating oligodendrocyte progenitor cell proliferation and differentiation within the brain.

    Debra Mayes

    Miller-Shyra-Ratner Lab_200
    Miller-Shyra-Ratner Lab_60

    Shyra Miller

    Shyra Miller

    Chandra Moon headshot.
    Chandra Moon headshot.

    Chandra Moon, BS

    Research assistant II studying Rac1 and Cdc42 function in conjunction with Li Guo. Responsibilities are managing the lab and maintaining mouse colonies.

    Chandra Moon

    Ami Patel headshot.
    Ami Patel headshot.

    Ami Patel

    Goal is to identify and study novel genes that play a key role in tumorigenesis in NF1 and / or MPNSTs. Project will focus on the 138 genes that are upregulated more than threefold in human neurofibroma tumors and MPNSTs.

    Ami Patel

    Deanna Patmore headshot.
    Deanna Patmore headshot.

    Deanna Patmore, BS

    UC graduate student studying the effects of neurofibromin mutation, unrelated to Ras-GTP, and whether it can be explained by the activation of the Ras protein of R-Ras2 / TC21.

    Deanna Patmore

    Carlos Prada headshot.
    Carlos Prada headshot.

    Carlos Prada, MD

    Pediatrics and genetics combined resident (PG-5) working with novel mast cell inhibitors to prevent plexiform neurofibroma formation in preclinical models of neurofibromatosis type 1 (NF1). Our goal is to identify novel potential therapeutic targets and biomarkers that can modify or prevent tumorigenesis to improve the lives of children with NF1.

    Carlos Prada

    Nancy Ratner headshot.
    Nancy Ratner headshot.

    Nancy Ratner, PhD

    Working to define the interactions between glial cells and axons during nervous system development and how those interactions go awry in disease. Her goal is to develop novel therapies for patients with nervous system diseases.

    Nancy Ratner

    Tilat Rizvi headshot.
    Tilat Rizvi headshot.

    Tilat Rizvi, PhD

    Assistant Professor researching oligodendrocytes in relation to demyelination and remyelination using a mouse model system for human disease neurofibromatosis type 1 (NF1).

    Tilat Rizvi

    Haley Titus headshot.
    Haley Titus headshot.

    Haley Titus

    Research project involves studying the molecular pathways of oligodendrocytes, the myelinating glia of the central nervous system, in the brain and spinal cord.  Interested in studying demyelination and remyelination for potential therapies for neurological disease, specifically NF1 and multiple sclerosis.

    Haley Titus

    Jianqiang Wu headshot.
    Jianqiang Wu headshot.

    Jianqiang Wu, MD, MS

    Research instructor working on neurofibroma origin in neurofibromatosis type 1 (NF1) and a preclinical therapeutic trial on neurofibromas. 

    Jianqiang Wu

  • Ratner Lab group shot.

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