• Huppert Lab Research

    huppert-article1-imageThe Huppert Lab is interested in intercellular signaling pathways that regulate cell fate decisions and lineage restriction during organogenesis and adult cell population renewal. Our projects use genetic, chemical and surgical mouse models, as well as primary cell lines to answer questions related to liver development and regeneration. 

    The liver is a vital organ for metabolism and homeostasis, and has the highest regenerative capacity of all parenchymal organs. The architecture of the liver biliary and vasculature systems is absolutely crucial for the overall health of the organ and the ability to perform its endocrine and exocrine functions. Generating continuity between canalicular networks, and establishing the biliary and vascular systems within the growing parenchymal mass involves finely tuned complex morphological and molecular mechanisms. The lack of knowledge relating important hepatic dimensional aspects limits our understanding for how paracrine and autocrine signals directly regulate or indirectly influence the intact communicating architecture and physiology. Our long-term goal is to define the molecular factors and cellular contribution required for formation of the two- and three-dimensional hepatic architecture, during hepatic morphogenesis, homeostasis and regeneration.  

    It is our hope that by elucidating the molecular mechanisms that guide cell-cell communication, epithelial-mesenchymal interactions and lineage restriction in the liver, we will gain novel insights into how defects in normal processes are dysregulated in congenital and chronic liver diseases.

    The Huppert lab trains graduate students who are in the Molecular and Developmental Biology Graduate Program, and the Cancer and Cell Biology Graduate Program.

  • Current Projects

    Learn more about current projects at the Huppert Lab.

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  • Meet the Lab

    Learn more about the members of the Huppert Lab.

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  • Contact Us

    huppert-cta3-headshot
    STACEY S. HUPPERT, Ph.D.
    Associate Professor
    Division of Gastroenterology, Hepatology & Nutrition
    Division of Developmental Biology
    Cincinnati Children’s Hospital Medical Center
    3333 Burnet Avenue
    Cincinnati, Ohio 45229
    Email: stacey.huppert@cchmc.org
    Office Phone: 513.803.3871
    Lab Phone: 513.636.4014