A photo of Stacey Huppert.

Associate Professor, UC Department of Pediatrics

513-803-3871

Biography & Affiliation

Research Interests

Hepatic cell plasticity, development and regeneration; reprogramming; three-dimensional hepatic architecture; Notch signaling; hepatobiliary disease

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Gastroenterology, Developmental Biology



Blog Posts

How Some Liver Cells Switch Identities to Build Missing Bile Ducts

Digestive System

How Some Liver Cells Switch Identities to Build Missing Bile Ducts

Stacey S. Huppert, PhD7/2/2019

Education

BS: Genetic Biology,Purdue University, West Lafayette, IN, 1992.

PhD: Genetics, Indiana University, Bloomington, IN, 1998.

Postdoctoral Fellow: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2003.

Instructor: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2005.

Assistant Professor: Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, 2012.

Publications

Selected Publication

Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Adams, JM; Huppert, KA; Castro, EC; Lopez, MF; Niknejad, N; Subramanian, S; Zarrin-Khameh, N; Finegold, MJ; Huppert, SS; Jafar-Nejad, H. Hepatology. 2020; 71:1331-1349.

Molecular regulation of mammalian hepatic architecture. Huppert, SS; Iwafuchi-Doi, M. Current Topics in Developmental Biology. 2019; 132:91-136.

De novo formation of the biliary system by TGF beta-mediated hepatocyte transdifferentiation. Schaub, JR; Huppert, KA; Kurial, SN T; Hsu, BY; Cast, AE; Donnelly, B; Karns, RA; Chen, F; Rezvani, M; Luu, HY; et al. Nature. 2018; 557:247-251.

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Broadus, MR; Chen, TW; Neitzel, LR; Ng, VH; Jodoin, JN; Lee, LA; Salic, A; Robbins, DJ; Capobianco, AJ; Patton, JG; et al. Cell Reports. 2016; 15:1920-1929.

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Preface. Wellik, DM; Huppert, SS; Sun, X; Walton, K; Brown, N; Forsberg, EC. In: Wellik DM, Ed. ORGAN DEVELOPMENT. : ELSEVIER ACADEMIC PRESS INC; ELSEVIER ACADEMIC PRESS INC; 2019.

Bile duct development and the notch signaling pathway. Huppert, SS; Campbell, KM. Alagille Syndrome: Pathogenesis and Clinical Management. : Springer International Publishing; Springer International Publishing; 2018.

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. Ng, VH; Hang, BI; Sawyer, LM; Neitzel, LR; Crispi, EE; Rose, KL; Popay, TM; Zhong, A; Lee, LA; Tansey, WP; et al. Journal of Cell Science. 2018; 131:jcs210575-jcs210575.

Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Soini, T; Pihlajoki, M; Andersson, N; Lohi, J; Huppert, KA; Rudnick, DA; Huppert, SS; Wilson, DB; Pakarinen, MP; Heikinheimo, M. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2018; 314:G547-G558.

Emerging advancements in liver regeneration and organogenesis as tools for liver replacement. Huppert, SS; Campbell, KM. Current Opinion in Organ Transplantation. 2016; 21:581-587.

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Huppert, SS; Iwakura, Y; Dong, C; Shanmukhappa, SK; Divanovic, S. PLoS ONE. 2016; 11:e0149783-e0149783.