A photo of Stacey Huppert.

Associate Professor, UC Department of Pediatrics

513-803-3871

Biography & Affiliation

Research Interests

Hepatic cell plasticity, development and regeneration; reprogramming; three-dimensional hepatic architecture; Notch signaling; hepatobiliary disease

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Gastroenterology, Developmental Biology

Science Blog

Education

BS: Genetic Biology,Purdue University, West Lafayette, IN, 1992.

PhD: Genetics, Indiana University, Bloomington, IN, 1998.

Postdoctoral Fellow: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2003.

Instructor: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2005.

Assistant Professor: Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, 2012.

Publications

Selected Publication

Molecular regulation of mammalian hepatic architecture. Huppert, SS; Iwafuchi-Doi, M. Current Topics in Developmental Biology. 2019; 132:91-136.

De novo formation of the biliary system by TGF beta-mediated hepatocyte transdifferentiation. Schaub, JR; Huppert, KA; Kurial, SN T; Hsu, BY; Cast, AE; Donnelly, B; Karns, RA; Chen, F; Rezvani, M; Luu, HY; et al. Nature. 2018; 557:247-251.

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Broadus, MR; Chen, TW; Neitzel, LR; Ng, VH; Jodoin, JN; Lee, LA; Salic, A; Robbins, DJ; Capobianco, AJ; Patton, JG; et al. Cell Reports. 2016; 15:1920-1929.

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY Preface. Wellik, DM; Huppert, SS; Sun, X; Walton, K; Brown, N; Forsberg, EC. In: Wellik DM, Ed. ORGAN DEVELOPMENT. : ELSEVIER ACADEMIC PRESS INC; ELSEVIER ACADEMIC PRESS INC; 2019.

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling. Ng, VH; Hang, BI; Sawyer, LM; Neitzel, LR; Crispi, EE; Rose, KL; Popay, TM; Zhong, A; Lee, LA; Tansey, WP; et al. Journal of Cell Science. 2018; 131:jcs210575-jcs210575.

Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Soini, T; Pihlajoki, M; Andersson, N; Lohi, J; Huppert, KA; Rudnick, DA; Huppert, SS; Wilson, DB; Pakarinen, MP; Heikinheimo, M. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2018; 314:G547-G558.

Emerging advancements in liver regeneration and organogenesis as tools for liver replacement. Huppert, SS; Campbell, KM. Current Opinion in Organ Transplantation. 2016; 21:581-587.

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Cappelletti, M; Huppert, SS; Iwakura, Y; Dong, C; Shanmukhappa, SK; Divanovic, S. PLoS ONE. 2016; 11:e0149783-e0149783.

A Faithful JAGGED1 Haploinsufficiency Mouse Model of Arteriohepatic Dysplasia (Alagille Syndrome) After All. Huppert, SS. Hepatology. 2016; 63:365-367.

Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction. Chen, J; Ryzhova, LM; Sewell-Loftin, MK; Brown, CB; Huppert, SS; Baldwin, HS; Merryman, WD. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35:1597-1605.