Kalfa Lab

  • Kalfa Lab Research

    Our laboratory is studying signaling within the erythroid progenitor and precursor cells during erythropoiesis, as well as in mature red blood cells.  We specifically focus on signals conducted by Rac GTPases, which are members of the Rho family and Ras superfamily. They switch between the inactive GDP-bound form and the active GTP-bound form to regulate a wide spectrum of cellular functions.  They have been shown to play unique and overlapping roles in hematopoietic and blood cells (Mulloyet al., Blood. 115:936–947. 2010). They control actin cytoskeleton, cell motility, vesicular transport pathways, reactive oxygen species production, as well as cell adhesion and migration, proliferation and survival.                                                               

    We explore the role of Rac GTPases in erythropoiesis and mature RBCs in gene-targeted mice where Rac1 and Rac2 GTPases have been deleted from the hematopoietic cells.  We also study the role of Rac GTPases in generation of reactive oxygen species (ROS) within human erythrocytes from patients with sickle-cell disease. 

 
 
  • Meet the Lab

    Find out who works in the Kalfa lab. 

    Meet the Lab
 
 
  • Blood Cover

    click to enlarge

    Blood Cover

    See the related article:
    Kalfa TA, et al. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood.108 (12) 3637. December 1, 2006

  • Contact Us

    For additional information, contact Theodosia Kalfa, MD, PhD, at the Cancer and Blood Diseases Institute, 513-636-0989.  Kalfa’s office is in room 7530 of the Cincinnati Children’s Research Foundation building.