MD: Aristotle University Medical School, Thessaloniki, Greece, 1990.

PhD: Aristotle University Medical School, Thessaloniki, Greece, 1997.

Residency: University Of North Carolina, Chapel Hill, NC, 1999.

Fellowship: Duke University Medical Center, Durham, NC, 2003.

Certification: Hematology / oncology, American Board of Pediatrics, 2004; Pediatrics, American Board of Pediatrics, 2000; ECFMG Certification, 1995.

Licenses: Full and unrestricted medical license (OH Medical Board), 2003-present; full and unrestricted license of medical practice in Greece, 1990-present.

Services and Specialties

Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders


Signaling in erythrocytes; erythropoiesis; sickle cell disease; reactive oxygen species

Research Areas

Experimental Hematology and Cancer Biology, Hematology, Cancer and Blood Diseases

Additional Languages


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VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. Seu, KG; Trump, LR; Emberesh, S; Lorsbach, RB; Johnson, C; Meznarich, J; Underhill, HR; Chou, ST; Sakthivel, H; Nassar, NN; Seu, KJ; Blanc, L; Zhang, W; Lutzko, CM; Kalfa, TA. The American Journal of Human Genetics. 2020; 107:1149-1156.


Red cell membrane disorders: structure meets function. Risinger, M; Kalfa, TA. Blood. 2020; 136:1250-1261.


Signaling and cytoskeletal requirements in erythroblast enucleation. Konstantinidis, DG; Pushkaran, S; Johnson, JF; Cancelas, JA; Manganaris, S; Harris, CE; Williams, DA; Zheng, Y; Kalfa, TA. Blood. 2012; 119:6118-6127.

Rapid measurement of hemoglobin-oxygen dissociation by leveraging Bohr effect and Soret band bathochromic shift. Sekyonda, Z; An, R; Goreke, U; Man, Y; Monchamp, K; Bode, A; Zhang, Q; El-Gammal, Y; Kityo, C; Kalfa, TA; Akkus, O; Gurkan, UA. The Analyst. 2024; 149:2561-2572.

Case report: Childhood erythrocytosis due to hypermanganesemia caused by homozygous SLC30A10 mutation. Coppola, T; Hughes, H; Finch, PT; Hess, JA; Wu, S; Prada, CE; Miethke, AG; Zhang, W; Kalfa, TA. 2024; 3:1331485.

A Population Pharmacokinetic Analysis of L-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects. Sadaf, A; Dong, M; Pfeiffer, A; Latham, T; Kalfa, T; Vinks, AA; Ware, RE; Quinn, CT. Clinical Pharmacokinetics. 2024; 63:357-365.

Red cell abnormalities characterized by ektacytometry in children with cholestasis. Kocoshis, TS; Kalfa, TA; Miethke, AG; Balistreri, WF; Seu, KG; Slaughter, CG; Singh, R; Mullen, M; Kocoshis, SA. Pediatric Research. 2024; 95:1035-1040.

Inducible Knockout of Codanin-1: An Adult Mouse Model of Congenital Dyserythropoietic Anemia Type-I. Azucenas, CR; Stewart, M; Voulgaridou, A; Seu, K; Kalfa, TA. Blood. 2023; 142:2450.

Irf5 Expression in Macrophages Contributes to Iron Regulation within Erythromyeloblastic Islands. Josselsohn, R; Vagrecha, A; LaPan, M; Papoin, J; Kamen, J; Cho, YM; Rao, R; Romano, L; Salomonis, N; Kalfa, TA; Blanc, L; Barnes, BJ. Blood. 2023; 142:920.

Rapid Assessment of Hemoglobin-Oxygen Dissociation. Sekyonda, Z; Kityo, C; Elgammal, Y; Kalfa, TA; Akkus, O; Gurkan, UA. Blood. 2023; 142:2270.

From the Blog

Blood Cell Production Discovery Opens Path to Improve Anemia of Inflammation
Tools for Science

Blood Cell Production Discovery Opens Path to Improve Anemia of Inflammation

Theodosia A. Kalfa, MD, PhD10/31/2022

Rare Disease Day: More Tools for Solving Diagnostic Mysteries
Rare Diseases

Rare Disease Day: More Tools for Solving Diagnostic Mysteries

Theodosia A. Kalfa, MD, PhD3/1/2021

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