Molkentin Lab

  • Molkentin Lab Research

    Dr. Molkentin looking in a microscope.

    In the News

    Read "New Leaders in Cardiovascular Science" in Circulation Research featuring Dr. Molkentin.

    Our laboratory investigates a range of focus areas, all of which center on understanding the molecular mechanisms of heart and skeletal muscle disease. Toward this end we study the basic machinery that underlies cell death, with a special interest in mitochondrial-dependent mechanisms of nonapoptotic death (such as cellular necrosis). Prominent diseases of both heart and skeletal muscle are affected by cellular necrosis, so identifying the genes that control this process could have a substantial effect on our treatment of these types of diseases.

    We are also interested in characterizing the intracellular signaling pathways that control cellular growth, differentiation and replication in cardiac and skeletal muscle. A better understanding of the signaling pathways that control these processes, coupled with the identification of novel genes, could suggest new treatment strategies for human diseases. Similarly, we are examining the transcriptional regulatory factors and epigenetic mechanisms that regulate cardiac and skeletal muscle differentiation, growth, death and replication, in order to suggest additional targets for treating human disease.

    Our laboratory is also actively engaged in identifying novel secreted protein factors in the heart (cytokines, growth factors, chemokines) that might control disease responsiveness. We study the cardiac fibroblast and how it functions during disease to alter the extracellular matrix, which affects heart remodeling. And we are investigating the basic mechanisms of intracellular calcium handling in cardiac and skeletal muscle to further understand the paradigms of excitation-transcription coupling and excitation-signaling coupling.

  • Research Interests
    Regulation of Cell Death Through the Mitochondria.
    Cell Death Through the Mitochondria
    Regulation of Cell Death Through the Mitochondria.
    Regulation of Cardiac Hypertrophy.
    Cardiac Hypertrophy
    Regulation of Cardiac Hypertrophy.
    Stem Cells in Cardiac Regeneration.
    Stem Cells in Cardiac Regeneration
    Stem Cells in Cardiac Regeneration.
    Regulation of Fibroblast Activity.
    Regulation of Fibroblast Activity
    Regulation of Fibroblast Activity.
    Regulation of Transcription.
    Transcription
    Regulation of Transcription.
    Mechanisms of Duchenne and Miyoshi Myopathy.
    Mechanisms of Duchenne and Miyoshi Myopathy
    Mechanisms of Duchenne and Miyoshi Myopathy.
    Regulation of Skeletal Muscle Development and Hypertrophy.
    Skeletal Muscle Development and Hypertrophy
    Regulation of Skeletal Muscle Development and Hypertrophy.
 
 
 
  • Meet Our Lab

    Learn more about the faculty, staff and student members of our research team.

    Meet the Lab