A photo of Jeffery Molkentin.

Jeffery D. Molkentin, PhD


  • Director, Division of Molecular Cardiovascular Biology
  • Co-Director, Heart Institute
  • Professor, UC Department of Pediatrics

About

Biography

I enjoy all areas of science but eventually focused on biological medical research. I find science fascinating and was always drawn to biomedical research. At Cincinnati Children’s — where I lead the Division of Molecular Cardiovascular Biology — I look for new molecular mechanisms of disease that might lead to new treatments.

My research interests include heart disease, muscular dystrophy, tissue fibrosis, calcium handling, ER stress signaling, cardiac hypertrophic signaling pathways and COVID-19 disease mechanisms.

Our laboratory has made significant contributions to the area of stem cell therapy for the heart. We have shown that presumed adult stem cells do not regenerate the heart. Instead, direct injection of these cells into the injured heart has a protective effect by altering the innate immune response and the activity of healing macrophages.

I have been a full investigator with the Howard Hughes Medical Institute since 2008. For my work, I have been awarded the Basic Research Prize from the American Heart Association.

I take great pride in helping young scientists who wish to pursue careers in biomedical research. Dozens of my past trainees have gone on to principle investigator roles at academic institutions.

Publications

Selected

MCUb Induction Protects the Heart From Postischemic Remodeling. Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. Circulation Research. 2020; 127:379-390.

Selected

Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Circulation. 2020; 141:1037-1039.

Selected

An acute immune response underlies the benefit of cardiac stem cell therapy. Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. Nature: New biology. 2020; 577:405-409.

Selected

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Correll, RN; Grimes, KM; Prasad, V; Lynch, JM; Khalil, H; Molkentin, JD. Scientific Reports. 2019; 9.

Selected

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Nature Communications. 2019; 10.

Selected

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Science advances. 2019; 5.

Selected

Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. JCI insight. 2019; 4.

Selected

Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. Journal of Biological Chemistry. 2019; 294:8918-8929.

Selected

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. JCI insight. 2019; 5.

Selected

Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Circulation. 2018; 138:2931-2939.

From the Blog


Cincinnati Children’s Launches 6 COVID-19 Research Projects
Infectious Diseases and Vaccines

Cincinnati Children’s Launches 6 COVID-19 Research Projects

Jeffery D. Molkentin, PhD, Ming Tan, PhD ...5/26/2020

Robbins Retires, Molkentin Named Director of Molecular Cardiovascular Biology
Heart and Lung

Robbins Retires, Molkentin Named Director of Molecular Cardiovascular Biology

Jeffery D. Molkentin, PhD6/30/2019

A Study That Changed the Direction of Cardiac Stem Cell Research
Heart and Lung

A Study That Changed the Direction of Cardiac Stem Cell Research

Jeffery D. Molkentin, PhD6/27/2019