I enjoy all areas of science but eventually focused on biological medical research. I find science fascinating and was always drawn to biomedical research. At Cincinnati Children’s — where I lead the Division of Molecular Cardiovascular Biology — I look for new molecular mechanisms of disease that might lead to new treatments.
My research interests include heart disease, muscular dystrophy, tissue fibrosis, calcium handling, ER stress signaling, cardiac hypertrophic signaling pathways and COVID-19 disease mechanisms.
Our laboratory has made significant contributions to the area of stem cell therapy for the heart. We have shown that presumed adult stem cells do not regenerate the heart. Instead, direct injection of these cells into the injured heart has a protective effect by altering the innate immune response and the activity of healing macrophages.
I have been a full investigator with the Howard Hughes Medical Institute since 2008. For my work, I have been awarded the Basic Research Prize from the American Heart Association.
I take great pride in helping young scientists who wish to pursue careers in biomedical research. Dozens of my past trainees have gone on to principle investigator roles at academic institutions.
BS: Marquette University, Milwaukee, WI, 1989.
PhD: Medical College of Wisconsin, 1994.
Heart, Fibrosis, Molecular Cardiovascular Biology
A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2213696120.
Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147:746-758.
Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 2022; 13:2940.
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12:3928.
Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144:328-331.
Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PloS one. 2021; 16:e0254667.
MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127:379-390.
Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.
An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10:76.
Jeffery D. Molkentin, PhD8/25/2023
Jeffery D. Molkentin, PhD2/8/2023
Jeffery D. Molkentin, PhD6/24/2021
Jeffery D. Molkentin, PhD3/22/2021
Jeffery D. Molkentin, PhD, Ming Tan, PhD ...5/26/2020
Jeffery D. Molkentin, PhD6/30/2019