Jeffery D. Molkentin, PhD

Executive Co-Director, Heart Institute

Director, Molecular Cardiovascular Biology

Professor | Howard Hughes Medical Institute Investigator

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3557

Fax 513-636-5958


Dr. Molkentin's research aims to understand the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation. His work has advanced the understanding of molecular events behind heart disease and muscular dystrophy.

In 2008 he was named a Howard Hughes Medical Institute (HHMI) investigator.

For a full description of Dr. Molkentin's work, please see his Faculty Lab Site in the Division of Molecular and Cardiovascular Biology.

BS: Marquette University, Milwaukee, WI, 1989.

PhD: Medical College of Wisconsin, 1994.

View PubMed Publications

Burr AR, Molkentin JD. Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy. Cell Death & Diff. 2015.

Kwong JQ, Lu X, Correll RN, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD. The mitochondrial calcium uniporter selectively matches metabolic output to acute contractile stress in the heart. Cell Reports. 2015;12:15-22.

Karch J, Molkentin JD. Regulated Necrotic Cell Death: The Passive Aggressive Side of Bax and Bak. Circ Res. 2015 May 22;116(11):1800-9.

Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM. Molkentin JD. Necroptosis interfaces with MOMP and the MPTP in mediating cell death. PLOS one. 2015;10(6):e0130520.

Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, JE Rabinowitz, Leask A, Molkentin JD. Genetic analysis of CTGF as an effector of TGF signaling and cardiac remodeling. Mol Cell Biol. 2015;35:2154-2164.

Kwong JQ, Molkentin JD. In sickness and health: role of the mitochondrial permeability transition pore in the heart. Cell Metabolism. 2014;21:206-214. 

Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD.  A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Dev. Cell. 2012 23:705-715.

Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, van Berlo JH, Willette RN, Molkentin JD. Unrestrained p38 MAPK Activation in Dusp1/4 Double Null Mice Induces Cardiomyopathy. Circ Res. 2013 Jan 4:112(1):48-56.

Lorts A, Schwanekamp JA, Baudino TA, McNally EM, Molkentin JD.  Deletion of periostin reduced muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-b pathway. Proc Natl Acad Sci USA. 2012 109:10978-10983.

Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012 149,1257-1268.