A photo of Jeffery Molkentin.

Director, Division of Molecular Cardiovascular Biology

Co-Director, Heart Institute

Professor, UC Department of Pediatrics

513-636-3557

513-636-5958

Biography & Affiliation

Biography

Jeffery D. Molkentin, PhD, is a professor in the Department of Pediatrics at the University of Cincinnati and Cincinnati Children's Hospital Medical Center. He received his BS from Marquette University in Milwaukee Wisconsin (USA) in 1989. He then received his PhD from the Medical College of Wisconsin in 1994, after which he performed postdoctoral training with Dr. Eric Olson in Texas (USA) from 1994-1997, followed by his first faculty appointment in 1997 at the Cincinnati Children’s Hospital Medical Center of the University of Cincinnati (USA). Dr. Molkentin has published over 400 original articles during this time, he has a Scopus H-index of 111. Dr. Molkentin was a Pew Scholar early in his career and is now a full investigator of the Howard Hughes Medical Institute in the USA since 2008. He has also won several awards such as the Louis N and Arnold M Katz award to young investigators and more recently the Basic Research Prize, both of the American Heart Association. Dr. Molkentin also won the Lucian Award from McGill University. He has also served on NIH study section and was an organizer of various national and international scientific meetings. Finally, Dr Molkentin has placed 35 of his past trainees into academics as laboratory principle investigators. Dr. Molkentin’s research program continues to focus on the identification of candidate genes and signaling pathways involved in cardiac hypertrophy, contractility, cell death, heart failure, fibrosis, regeneration and muscular dystrophy, as well as mitochondria-dependent necrosis.

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Heart, Fibrosis, Molecular Cardiovascular Biology

Science Blog

Education

BS: Marquette University, Milwaukee, WI, 1989.

PhD: Medical College of Wisconsin, 1994.

Publications

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Science Advances. 2019; 5:eaaw4597-eaaw4597.

Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. JCI insight. 2019; 4.

Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. The Journal of biological chemistry. 2019; 294:8918-8929.

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. JCI insight. 2019; 5.

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease. Murphy, E; Bernardi, P; Cohen, M; Di Lisa, F; Forte, M; Molkentin, JD; Ovize, M. Circulation Research. 2019; 124:1294-1296.

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve. Altamimi, TR; Karwi, QG; Uddin, GM; Fukushima, A; Kwong, JQ; Molkentin, JD; Lopaschuk, GD. Journal of Molecular and Cellular Cardiology. 2019; 127:223-231.

Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Circulation. 2018; 138:2931-2939.

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart. Neidig, LE; Weinberger, F; Palpant, NJ; Mignone, J; Martinson, AM; Sorensen, DW; Bender, I; Nemoto, N; Reinecke, H; Pabon, L; et al. Circulation. 2018; 138:2960-2962.

Myofibroblast-Specific TGF beta Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Meng, Q; Bhandary, B; Bhuiyan, MS; James, J; Osinska, H; Valiente-Alandi, I; Shay-Winkler, K; Gulick, J; Molkentin, JD; Blaxall, BC; et al. Circulation Research. 2018; 123:1285-1297.

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Stremmel, C; Schuchert, R; Wagner, F; Thaler, R; Weinberger, T; Pick, R; Mass, E; Ishikawa-Ankerhold, HC; Margraf, A; Hutter, S; et al. Nature Communications. 2018; 9.