Fibrosis is the excessive deposition of extracellular matrix that results in tissue scarring and organ dysfunction; it is a key component in the pathogenesis of many pediatric and adult diseases. It is estimated that 45% of deaths in the developed world are due to fibrosis-induced organ failure. Unfortunately, there are essentially no effective therapeutic options to attenuate or reverse fibrosis. This underscores the need for a synergistic, multidisciplinary approach to translational research in fibrosis.

The Center for Translational Fibrosis Research (CTFR) aims to establish Cincinnati Children's as a leader in innovative, translational research in organ fibrosis. CTFR integrates Cincinnati Children's impressive, existing, innovative strengths in lung, liver, kidney and heart fibrosis research efforts across basic, translational, imaging and clinical research. By studying similarities and differences across organs, CTFR will accelerate our understanding of fibrotic processes and synergize our efforts for diagnostic and therapeutic discovery/validation.