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Squamous cell carcinoma (SCC) is the second most common form of skin cancer, with more than 250,000 new cases a year estimated in the United States. Infection with the human papillomaviruses (HPVs) and expression of the two viral oncogenes E6 and E7 are one well defined cause.
The high-risk HPV types cause anogenital malignancies such as cervical cancer and a substantial proportion of head and neck cancers. The HPV vaccine Gardasil reduces disease burden, but its high cost, dosing regimen and the lack of protection for individuals already infected pose major obstacles to the field. Therapeutic vaccines and effective antivirals are not yet available.
The goal of our studies is to advance our understanding of both HPV-related and -unrelated SCC development, and to develop new approaches to the diagnosis and treatment of HPV as a major cause of cancer worldwide.
Two major areas of investigation in the laboratory focus on:
More recent studies are focused on the role of specific cellular proteins that were previously identified in the HPV context in the development and metastasis of human and murine breast cancer.
Learn more about the Wells lab human papillomavirus research on identifying cellular oncogenes and tumor suppressors.
Members of the Wells laboratory are a diverse group of students, postdoctoral and clinical fellows and research assistants with specific interests in basic, bioinformatics and translational research.
Susanne Wells, PhD3333 Burnet Ave.MLC 7015Cincinnati, OH 45229-3039
Phone (S. Wells): 513-636-5986Phone (Laboratory): 513-636-5967Fax: 513-636-2880
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900
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