A photo of Susanne Wells.

Director, Epithelial Carcinogenesis and Stem Cell Program

Professor, UC Department of Pediatrics

513-636-5986

513-636-3549

Biography & Affiliation

Biography

Susanne Wells graduated from the University of Konstanz, Germany, with a degree in Biology. She completed her PhD in Molecular Genetics and Microbiology at the State University of Stony Brook, NY, and her Postdoctoral Fellowship at Harvard Medical School, MA. Dr. Wells moved to Cincinnati Children's Hospital Medical Center in 2002 to study epithelial carcinogenesis and stem cells.

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Oncology, Cancer and Blood Diseases

Education

BS: Biology, University of Konstanz, Germany, 1992.

PhD: Molecular Genetics, State University of Stony Brook, NY, 1997.

Postdoctoral Fellowship: Molecular Virology, Harvard Medical School, Boston, MA.

Publications

Selected Publication

Cancer cell metabolism: Implications for x-ray and particle radiation therapy. Sertorio, M; Perentesis, JP; Vatner, RE; Mascia, AE; Zheng, Y; Wells, SI. International journal of particle therapy. 2019; 5:40-48.

Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. Toptan, T; Brusadelli, MG; Turpin, B; Witte, DP; Surralles, J; Velleuer, E; Schramm, M; Dietrich, R; Brakenhoff, RH; Moore, PS; et al. PLoS ONE. 2018; 13:e0209235-e0209235.

Lipidomic Profiling Links the Fanconi Anemia Pathway to Glycosphingolipid Metabolism in Head and Neck Cancer Cells. Zhao, X; Brusadelli, MG; Sauter, S; Kovacic, MB; Zhang, W; Romick-Rosendale, LE; Lambert, PF; Setchell, KD R; Wells, SI. Clinical Cancer Research. 2018; 24:2700-2709.

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. Matrka, MC; Cimperman, KA; Haas, SR; Guasch, G; Ehrman, LA; Waclaw, RR; Komurov, K; Lane, A; Wikenheiser-Brokamp, KA; Wells, SI. PLoS Genetics. 2018; 14:e1007227-e1007227.

Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know. Khoury, R; Sauter, S; Kovacic, MB; Nelson, AS; Myers, KC; Mehta, PA; Davies, SM; Wells, SI. Viruses-Basel. 2018; 10:47-47.

The nuclear DEK interactome supports multi-functionality. Smith, EA; Krumpelbeck, EF; Jegga, AG; Prell, M; Matrka, MM; Kappes, F; Greis, KD; Ali, AM; Meetei, AR; Wells, SI. Proteins: Structure, Function, and Bioinformatics. 2018; 86:88-97.

Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. Matrka, MC; Watanabe, M; Muraleedharan, R; Lambert, PF; Lane, AN; Romick-Rosendale, LE; Wells, SI. PLoS ONE. 2017; 12:e0177952-e0177952.

DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma. Smith, EA; Kumar, B; Komurov, K; Smith, SM; Brown, NV; Zhao, S; Kumar, P; Teknos, TN; Wells, SI. Oncotarget. 2017; 8:23414-23426.

DEK is required for homologous recombination repair of DNA breaks. Smith, EA; Gole, B; Willis, NA; Soria, R; Starnes, LM; Krumpelbeck, EF; Jegga, AG; Ali, AM; Guo, H; Meetei, AR; et al. Scientific Reports. 2017; 7.

Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Chlon, TM; Ruiz-Torres, S; Maag, L; Mayhew, CN; Wikenheiser-Brokamp, KA; Davies, SM; Mehta, P; Myers, KC; Wells, JM; Wells, SI. Stem Cell Reports. 2016; 6:44-54.