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The goal of the Sinner Lab is to understand the molecular mechanisms underlying the patterning of the mammalian respiratory tract during normal development and congenital disease. We focus on the paracrine interactions between two major components of the developing lung:
Cross talk between epithelium and mesenchyme is paramount to the differentiation of pulmonary cell lineages. Epithelial-Mesenchymal interactions are mediated by signaling pathways and transcription factors including the Wnt signaling pathway and Sox transcription factors, which are object of our studies. Our experimental approaches include genetic studies using transgenic mice and in vitro cell and organ culture.
1. Understanding how the developing pulmonary epithelium induces mesenchymal and endothelial cell differentiation. 2. Defining how the muscle and chondrocyte cell lineages are established in the developing trachea.
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