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Jeffrey Whitsett’s laboratory makes extensive use of conditional gene targeting in transgenic mice, bioinformatics, physiology and biochemistry in the study of lung formation and function. Transgenic mice models are utilized to understand the pathogenesis of genetic and inflammatory lung disorders and to develop new therapies for respiratory disease. Conditional systems for gene targeting have been developed for study of lung formation and function, as well as for identifying lung progenitor cells and their fates in the mouse.
Currently, the Whitsett laboratory seeks to:
click to enlarge
Figure 1 shows human lung histology. NL is normal distal lung. Next are patients with genetic mutations in: surfactant protein B (SFTPB), ABCA3, surfactant protein C (SFTPC) and pulmonary alveolar proteinosis (PAP).
Jeffrey A. Whitsett, MD
Division of Pulmonary Biology3333 Burnet Ave. Cincinnati, OH 45229-3039
Phone: 513-803-2790Email: email@example.com
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