Jeffery D. Molkentin, PhD
Appointment
Professor
Email
jeff.molkentin@chmcc.org
Phone
513-636-3557
Fax
513-636-5958
Bio
For a full description of Jeff Molkentin's work, please see his Faculty Lab Site in the Division of Molecular and Cardiovascular Biology.
Credentials
BS Marquette University, Milwaukee WI, 1989
PhD: Medical College of Wisconsin, 1994.
Publications, Most Recent
See Jeff Molkentin's lab web site for a full listing of recent publications.
Editorial Boards
2001-present Editorial Board of the Journal of Molecular and Cellular Cardiology
2002-present Editorial board member of Circulation
2004-2007 Editorial Board for Physiological Reviews
2004-present Editorial board member of Circulation Research
1998- present Ad hoc reviewer for: Journal of Biological Chemistry, Nature Reviews, Development, Journal of Clinical Investigation, Journal of Cell Biology, Nature Medicine, Proc. Natl. Acad. of Sciences, Molecular and Cellular Biology, Developmental Biology, American Journal of Physiology
Lectures and addresses (last 3 years)
2007 "Regulation of Necrotic cell death through the mitochondria" Invited speaker. Scripps Institute, Florida. March 16th
2007 "Calcium regulates cardiac contractility, hypertrophy, and cell death". Invited speaker. University of Rochester School of Medicine, Department of Cardiology. March 7th
2007 "The three faces of calcium in the heart: contractility, hypertrophy and cell death. Invited speaker. Loyola University School of Medicine (cardiology), Feb 15th
2007 "Calcium regulates cardiac contractility, hypertrophy and cell death. Invited speaker. Institute for Molecular Medicine, University of Texas. Feb 9th
2006 "Calcium regulatory pathways controlling cardiac disease and adaptation. Invited speaker. Gladstone at UCSF, Cardiovascular Division. Dec 18th
2006 "Mitochondrial-dependent cell death: role of the pore." Invited speaker. MDC, Department of Cardiology, Berlin, Germany, Oct 26th
2006 "What is the mitochondrial pore and does it regulate cell death?" Keynote speaker, Tufts-Cardiology department yearly retreat, Woods Hole MA, Sept 20-21.
2006 "Role of GDF-15 in protecting the myocardium" Speaker. 10th annual HFSA meeting in Seattle. Sept 10-13
2006 "Role of mitochondrial permeability in cardiac necrosis: role of VDAC. Speaker. AHA BSCV 3rd annual summer meeting. Keystone CO, July 31-Aug 3rd.
2006 "Calcium toxicity induced by beta2a expression in the heart" Speaker. Cardiac regulatory mechanisms. Gordon Conference. New London NH, July 16-21
2006 "Calcium toxicity induced by beta2a expression in the heart" Speaker. Excitation-Contraction Coupling. Gordon Conference. New London NH, June 4-9
2006 "Role of calcineurin in skeletal muscle and muscular dystrophy". Speaker. Skeletal Muscle Meeting, Dallas TX, April 23-26.
2006 "Regulation of Physiologic vs. Pathologic cardiac hypertrophy. Speaker, German Society of Cardiology Annual meeting, Mannheim Germany, April 20-22.
2006 "Signaling pathways regulating cardiac growth". Invited Speaker, Marquette University. Milwaukee WI. April 7th
2006 "GDF-15 as a novel cardioprotective factor released from the heart" Invited Speaker. Scios Inc, Fremont CA. March 17th.
2006 "ERKs are not necessary for cardiac hypertrophy in vivo" Invited Speaker. Keystone Symposia, Santa Fe, NM, Feb 19-24.
2006 "Calcineurin-NFAT and the MAPKs control Cardiac Hypertrophy". Invited seminar speaker, University of Maryland, Baltimore MD. Feb 9th.
2005 "Role of p38 MAPK in the heart" Invited speaker, American Heart Association, Dallas TX, Nov 13-16
2005 "Gata4: Not just for cardiac development anymore." UT Southwestern, Olson Laboratory faculty reunion meeting. Dallas TX, Sept 24,25
2005 "New insights into mitochondrial permeability transition in cell death" HFSA meeting in Boca Raton, FL, Sept 18-21
2005 "GDF-15 is a novel cardioprotective paracrine factor" Invited Speaker, AHA Summer Basic Science meeting, Keystone CO July 24-27
2005 "What source of calcium regulates cardiac hypertrophy?" Invited Speaker. Mammalian Myocardium, Bristol England, July 18-20.
2005 "Signaling pathways involved in muscular dystrophy" Invited Speaker. Parent Project Muscular Dystrophy (PPMD). Cincinnati, OH July 7-10
2005 "Role of GDF-15 in heart failure and cardioprotection" Invited Speaker. European Society of Cardiology (ESC), Lisbon Portugal, June 12-15
2005 "Cyclophilin D regulates mitochondrial permeability transition: a required aspect of cell death". Invited Speaker, U. South Dakota. Sioux Falls May 31st.
2005 "Mitochondrial pore function in cell death". Speaker. Keystone Symposium on the myocardium. Steamboat Springs, April 3rd-8th
2005 "Myostatin as a regulator of muscular dystrophy" Speaker. Parent Project muscular dystrophy (PPMD)satellite meeting, Washington DC, March 6th.
2005 "Cyclophilin D regulates mitochondrial permeability transition: a required aspect of cell death". Invited Speaker, UNC Chapel Hill. Chapel Hill, NC. Feb 14th.
2005 "Cyclophilin D regulates mitochondrial permeability transition: a required aspect of cell death". Invited Speaker, Oregon Health Science Univ. Portland OR, Jan 31st.
2004 "Calcium-calcineurin regulate divergent functions in cardiac and skeletal muscle. Invited Speaker. EMBO calcium-regulatory meeting, Capri Italy. Sept 20-23
2004 "Role of Calcineurin-NFAT in cardiac and skeletal muscle". Invited speaker, University of Iowa, Department of Physiology, Iowa City IA. August 31st.
2004 "Genetic analysis of Calcineurin-NFAT function in the heart". Invited lecturer, University of Vermont, Department of Pharmacology, Burlington VA, August 11th
2004 "Calcineurin-NFAT signaling in regulating cardiac hypertrophy". Invited lecturer, Wyeth Pharmaceuticals, Collegeville PA. August 9th
2004 "PKCalpha regulates cardiac contractility and heart failure". Speaker, 1st annual AHA basic science meeting, Skamania Lodge, Washington State. July 14th-18th
2004 "PKCalpha regulates cardiac contractility and heart failure propensity." Invited Speaker, Gordon Conference Cardiac Regulatory Mechanisms. Colby-Sawyer Coll., June 5-10
2004 "PKCalpha regulates cardiac contractility and heart failure propensity." Keynote Speaker, Cleveland Clinic & Case Western Reserve 1st annual combined Cardiovascular Meeting, Cleveland. June 2nd
2004 "Intracellular signaling pathways controlling cardiac hypertrophic growth." Invited Speaker, Medical College of Georgia, Augusta GA, Dept of Physiology May 24
2004 "PKCalpha regulates cardiac contractility and heart failure propensity." Invited Speaker, Boston University School of Medicine. Whitaker Cardio Institute. May 11
2004 "Deletion of PKCalpha protects the heart from failure."Invited Speaker. ISHR North America Chapter meeting in Cancun Mexico, May 1-4
2004 "Role of MAPK signaling in ischemia-reperfusion injury"Invited Speaker. ISHR North America Chapter meeting in Cancun Mexico, May 1-4
2004 "Novel signaling targets for heart failure" Invited Speaker. Cardiovascular Cell and Gene Therapy Conference II, Boston MA April 13-16
2004 "PKCalpha regulates cardiac contractility and heart failure propensity." Invited Speaker, University of Toronto, Heart and Stroke Center, Canada. April 5th
2004 "PKCalpha regulates cardiac contractility and heart failure propensity. Invited Speaker, UMDNJ, Cardiovascular Research Institute, New Jersey March 24.
2004 "p38 as a molecular target in heart disease" Speaker. Amgen, Thousand Oaks CA, Feb 3rd
2004 "PKC is a novel regulator of cardiac contractility and heart failure propensity" Speaker, Dept of Medicine, UCLA Medical Center, Los Angeles CA Feb 2nd
2003 "Calcineurin and MAPK co-regulation. Invited Speaker. Juan March Institute for internations meetings on Biology. Calcineurin-NFAT conference, Madrid. Nov 3-5
2003 "Role of PKCalpha as a mediator of cardiac contractility in vivo. Invited Speaker. HFSA meeting (Heart Failure Society of America). Las Vegas NV. Sept 20-24
2003 "Dissection of MAPK involvement in cardiac apoptosis in vivo. Invited Speaker. AHA Heart failure mechanisms and cell death meeting. Snowbird Utah. August 13-17
2003 "Role of GATA transcription factors in regulating cardiac hypertrophy" Invited Speaker. International GATA factor meeting. Montreal Canada. July 16-18.
2003 "Mechanisms of calcineurin-NFAT activation in the heart" Invited Speaker. Grodon Research Conference (GRC) on calcium regulation. South Hadley MA. July 6-10th
2003 "Mechanisms of calcineurin-NFAT activation in the heart" Invited Speaker. ESC/ISHR European meeting, Strasbourg France. June 21-24
2003 "Regulation of cardiac hypertrophy by signaling pathways." Invited Speaker. 4th conference on peptide growth factors in heart disease, Oulu Finland. Jun 5-6
2003 "Pharmacologic targets in cardiovascular disease" Regeneron Pharmaceuticals, TarryTown NY, May 13th
2003 "Calcineuin regulates pathologic but not physiologic cardiac hypertrophy. Speaker Dept of Medicine, Cardiology, Temple University (Grand Rounds) April 25th.
2003 "Role of p38 MAPK in cardiac hypertrophy and apoptosis" Speaker. Special p38 symposium in London UK at St. Thomas Hospital, March 21st
2003 "MAPK and Calcineurin Signaling Pathways Regulate Cardiac Growth" Univ. or Pittsburgh, Dept of Pharmacology Feb 14th
Grant support (Current)
Principal Investigator: "Cardiac Hypertrophic Intracellular Signaling Pathways" (NIH R01HL62927)
08/01/99 - 07/31/08; Yearly direct costs $200,000
Principal Investigator: "Molecular Pathways Controlling Cardiac Hypertrophy" (NIH R01HL60562)
07/01/98 - 06/30/08; Yearly direct costs $225,000
Component leader: "Role of PKC in Heart Failure." (NIH SCoR P01HL077101)
01/01/05 - 12/31/09; Yearly direct costs $245,887
Principal Investigator: "Mitochondrial regulated cell death" (NIH R01HL081104)
07/01/05 - 06/30/09; Yearly direct costs $250,000
Component leader: "Signaling pathways regulating cardiac disease." (NIH P01HL060770)
06/01/02 - 05/31/07; Yearly direct costs $194,764
Principal Investigator: American Heart Association Established Investigator Award
01/01/03 - 12/31/06; Yearly direct costs $91,000
Stipend and benefit support is available to qualified candidates through NHLBI Training Grant: T-32 HL07382-30: "Training In Cardiovascular Biology", Dr. Arnold Schwartz, Principal Investigator.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
