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High Res

Richard A. Lang, PhD

Director of the Visual Systems Group

Professor, UC Department of Pediatrics

Phone: 513-636-2700

Fax: 513-803-0740

Email: richard.lang@cchmc.org

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Specialties

Wnt Ligands in Tumorigenesis; Vascular Regression and Tissue Regeneration; Lens Induction and Morphogenesis

Visit the Lang Lab.

Education and Training

BSc: 1984 (with honors), University of Melbourne, Australia. Co-major in genetics and biochemistry.

PhD: 1988, University of Melbourne, Australia, at the Ludwig Institute for Cancer Research under Drs. AR Dunn and TJ Gonda.

Postdoctoral Fellow: 1989-92, The G.W. Hooper Research Foundation, University of California, San Francisco under Dr. JM Bishop. Studied the role of the macrophage in developmentally programmed tissue remodeling.

Publications

View PubMed Publications

Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA. Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8.

Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene. 2010 Jun 24;29(25):3715-22.

Plageman TF Jr, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA. Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. Development. 2010 Feb;137(3):405-15.

Smith AN, Radice G, Lang RA. Which FGF ligands are involved in lens induction? Dev Biol. 2010 Jan 15;337(2):195-8.

Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA. Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination. Development. 2009 Nov;136(21):3657-67.

Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Development. 2009 Sep;136(17):2977-85. Erratum in: Development. 2009 Oct;136(19):3377.

Rao S, Lobov IB, Vallance JE, Tsujikawa K, Shiojima I, Akunuru S, Walsh K, Benjamin LE, Lang RA. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development. 2007 Dec;134(24):4449-58.

Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development. 2007 May;134(10):1873-85.

Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007 Apr 10;5:15.

Miller LA, Smith AN, Taketo MM, Lang RA. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol. 2006 Mar 15;6:14.

Grants

Rho GTPases in early eye development. National Institute of Health. Apr 2007- Mar 2012. #R01 EY017848.

Macrophage and tumor angiogenesis. Co-Principal Investigator. National Institute of Health. Dec 2007- Nov 2012. #R01 CA131270.

Targeting Survival Factors for Ocular Neovascularization. National Institute of Health. Apr 2008- Mar 2012. #R01 EY012609.

CRIM1-β-catenin-Cadherin interactions in Eye Development and Disease. MPI with Dr. Rashmi Hegde of Cincinnati Children’s Hospital Medical Center. National Institute of Health. Apr 2009- Mar 2014. #R01 EY019377.

Sox2 and Pax6 in Eye development. Co-Principal Investigator. US-Israel Binational Science Foundation.
Feb 2009- Jan 2013.

Eyes absent phosphatase inhibitors in eye disease. MPI with Dr. Rashmi Hegde of Cincinnati Children’s Hospital Medical Center. National Institute of Health. Apr 2009- Mar 2014. #R21 EY019125.