Biographies

James M. Wells, PhD

Director, Basic Research, Division of Endocrinology

Director, Pluripotent Stem Cell Center

Professor, UC Department of Pediatrics

Phone: 513-636-8767

Fax: 513-636-4317

Email: james.wells@cchmc.org

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Specialties

identifying the molecular mechanisms involved in the development of the pancreas, liver and biliary system; replacement therapies, such as transplantable pancreatic beta cells for patients with type-1 diabetes; regeneration of adult tissues

Visit the Wells Lab.

Biography

The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.

Education and Training

BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.

PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.

Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001. 

Publications

View Dr. Wells PubMed Publications.

Grants

Single Cell Dissection of Human Intestine Development. Principal Investigator. National Institutes of Heath. Sept 2013 – Aug 2018. NIH 1R01DK098350.

Control of human endocrine cell development. Contact Principal Investigator. National Institutes of Heath. April 2012 – March 2017. NIH 1R01DK092456-01.

Develop Innovative Translational Tools to Study Enteroendocrine Function in Human Intestine and Applications to Diabetes Drug Discovery. Principal Investigator. Eli Lilly Internal Sponsors: Drs. Melissa Thomas and Hsiu Chiung-Yang. Dec 2011 – Nov 2013.

Generating Human Intestinal Organoids with an ENS. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1U18NS080815-01.

Generating 3-D lung organoids in vitro. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1R21 HL115372-01.

KLF5 regulation of intestinal development and stem cell homeostasis. Co-Investigator. National Institutes of Health. Aug 2011 – July 2015. NIH 1R01 DK092306-01.

Transcriptional Control of Placental Differentiation. Co-Investigator. National Institutes of Health. Feb 2011 – Jan 2016. NIH R01 HD065339.