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Specialties
Molecular and cellular mechanisms of embryoinc endoderm development and organ formation
Visit the Zorn Lab.
Education and Training
BSc University of Toronto, Canada.
PhD University of Texas, Austin, Texas, 1995.
Postdoctoral Wellcome Trust Cancer Research Campaing Institute, University of Cambridge, Cambridge, England, 1996-1999.
Research Fellow Wellcome Trust Gurdon Institute, Universtiy of Cambridge, Cambridge, England, 1999-2002.
Publications
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Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2010 Dec 12
Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn. 2010 Jan;239(1):56-68. Review.
Rankin SA, Hasebe T, Zorn AM, Buchholz DR. Improved cre reporter transgenic Xenopus. Dev Dyn. 2009 Sep;238(9):2401-8.
Zorn AM, Wells JM. Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol. 2009;25:221-51. Review.
Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA. Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS One. 2009 May 27;4(5):e5711.
Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev. 2008 Nov 1;22(21):3050-63.
Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007 Nov;27(22):7802-15.
McLin VA, Rankin SA, Zorn AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development. 2007 Jun;134(12):2207-17. Epub 2007 May 16.
Zorn AM, Wells JM. Molecular basis of vertebrate endoderm development. Int Rev Cytol. 2007;259:49-111. Review.
Mir A, Kofron M, Zorn AM, Bajzer M, Haque M, Heasman J, Wylie CC. FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. Development. 2007 Feb;134(4):779-88.
Grants
Mammalian liver and foregut development. Co-Principal Investigator. National Institutes of Health. Jan 2009 - Dec 2014. #R01 DK080823.
Molecular basis of liver development. Principal Investigator. National Institutes of Health. Apr 2007- Mar 2012. # R01DK07858.
